Is combined etanercept and methotrexate more efficacious than either monotherapy for treating ra?


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Access through your institution Buy or subscribe boxed-textvan der Heijde D _ et al_. (2006) Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid


arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial. _Arthritis Rheum_ 54: 1063–1074 BACKGROUND This is a preview of subscription


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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Bathon JM _ et al_. (2002) A comparison of etanercept and


methotrexate in patients with early rheumatoid arthritis. _N Engl J Med_ 343: 1586–1593 Article  Google Scholar  * Genovese MC _ et al_. (2002) Etanercept versus methotrexate in patients


with early rheumatoid arthritis: two-year radiographic and clinical outcomes. _Arthritis Rheum_ 46: 1443–1450 Article  CAS  Google Scholar  * Breedveld FC _ et al_. (2006) The PREMIER study:


a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early,


aggressive rheumatoid arthritis who had not had previous methotrexate treatment. _Arthritis Rheum_ 54: 26–37 Article  CAS  Google Scholar  * St Clair EW _ et al_. (2004) Combination of


infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial. _Arthritis Rheum_ 50: 3432–3443 Article  CAS  Google Scholar  * Pincus T _ et al_. (2006)


Declines in number of tender and swollen joints in patients with rheumatoid arthritis seen in standard care in 1985 versus 2001: possible considerations for revision of inclusion criteria


for clinical trials. _Ann Rheum Dis_ 65: 878–883 Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS The synopsis was written by Jasmine Farsarakis, Associate Editor, Nature


Clinical Practice. AUTHOR INFORMATION AUTHOR NOTES * CO BINGHAM IS AN ASSISTANT PROFESSOR AND JM BATHON IS A PROFESSOR AT THE JOHNS HOPKINS UNIVERSITY IN BALTIMORE, MD, USA * Clifton O


Bingham Authors * Clifton O Bingham View author publications You can also search for this author inPubMed Google Scholar * Joan M Bathon View author publications You can also search for this


author inPubMed Google Scholar ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS


ARTICLE CITE THIS ARTICLE Bingham, C., Bathon, J. Is combined etanercept and methotrexate more efficacious than either monotherapy for treating RA?. _Nat Rev Rheumatol_ 2, 534–535 (2006).


https://doi.org/10.1038/ncprheum0299 Download citation * Received: 30 June 2006 * Accepted: 26 July 2006 * Issue Date: 01 October 2006 * DOI: https://doi.org/10.1038/ncprheum0299 SHARE THIS


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