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Access through your institution Buy or subscribe boxed-textvan der Heijde D _ et al_. (2006) Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid
arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial. _Arthritis Rheum_ 54: 1063–1074 BACKGROUND This is a preview of subscription
content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue
Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL
ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Bathon JM _ et al_. (2002) A comparison of etanercept and
methotrexate in patients with early rheumatoid arthritis. _N Engl J Med_ 343: 1586–1593 Article Google Scholar * Genovese MC _ et al_. (2002) Etanercept versus methotrexate in patients
with early rheumatoid arthritis: two-year radiographic and clinical outcomes. _Arthritis Rheum_ 46: 1443–1450 Article CAS Google Scholar * Breedveld FC _ et al_. (2006) The PREMIER study:
a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early,
aggressive rheumatoid arthritis who had not had previous methotrexate treatment. _Arthritis Rheum_ 54: 26–37 Article CAS Google Scholar * St Clair EW _ et al_. (2004) Combination of
infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial. _Arthritis Rheum_ 50: 3432–3443 Article CAS Google Scholar * Pincus T _ et al_. (2006)
Declines in number of tender and swollen joints in patients with rheumatoid arthritis seen in standard care in 1985 versus 2001: possible considerations for revision of inclusion criteria
for clinical trials. _Ann Rheum Dis_ 65: 878–883 Article CAS Google Scholar Download references ACKNOWLEDGEMENTS The synopsis was written by Jasmine Farsarakis, Associate Editor, Nature
Clinical Practice. AUTHOR INFORMATION AUTHOR NOTES * CO BINGHAM IS AN ASSISTANT PROFESSOR AND JM BATHON IS A PROFESSOR AT THE JOHNS HOPKINS UNIVERSITY IN BALTIMORE, MD, USA * Clifton O
Bingham Authors * Clifton O Bingham View author publications You can also search for this author inPubMed Google Scholar * Joan M Bathon View author publications You can also search for this
author inPubMed Google Scholar ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS
ARTICLE CITE THIS ARTICLE Bingham, C., Bathon, J. Is combined etanercept and methotrexate more efficacious than either monotherapy for treating RA?. _Nat Rev Rheumatol_ 2, 534–535 (2006).
https://doi.org/10.1038/ncprheum0299 Download citation * Received: 30 June 2006 * Accepted: 26 July 2006 * Issue Date: 01 October 2006 * DOI: https://doi.org/10.1038/ncprheum0299 SHARE THIS
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