High initial levels of comorbidity in patients with ra selected to receive biologic agents


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Access through your institution Buy or subscribe Hyrich K _ et al_. (2006) Baseline comorbidity levels in biologic and standard DMARD treated patients with rheumatoid arthritis: results from


a national patient register. _Ann Rheum Dis_ 65: 895–898 Although the pivotal, randomized, controlled trials of biologic therapies for rheumatoid arthritis (RA) did not show an increase in


serious adverse events in biologic-agent-treated patients compared with placebo-treated patients, there has been concern about the safety of biologic agents in routine practice, because


those trials excluded patients with substantial comorbidity. Indeed, there have been reports of increases in serious adverse events in patients who receive biologic agents; however, before


these events can be attributed to the new treatments, the baseline comorbidity of patients selected for biologic treatment should ascertained. British investigators, therefore, carried out a


national, prospective, observational study to identify the prevalence and types of comorbidity in RA patients treated with biologic agents. This is a preview of subscription content, access


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levels of comorbidity in patients with RA selected to receive biologic agents. _Nat Rev Rheumatol_ 2, 525 (2006). https://doi.org/10.1038/ncprheum0294 Download citation * Issue Date: October


2006 * DOI: https://doi.org/10.1038/ncprheum0294 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is


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