Pain and depression cause fatigue in patients with ra

Access through your institution Buy or subscribe Pollard LC _ et al_. (2006) Fatigue in rheumatoid arthritis reflects pain, not disease activity. _Rheumatology_ 45: 885–889 Fatigue is a

common complaint of patients with active rheumatoid arthritis (RA), and it is well-known that treatment with anti-tumor necrosis factor (anti-TNF) agents or disease-modifying antirheumatic

drugs (DMARDs) can reduce RA patients' fatigue levels. The results of two studies by Pollard _ et al_. have now shown that the improvements in fatigue that occur with RA therapy depend

on improvements in patients' levels of pain and depression, rather than on reductions in disease activity. These results suggest that RA-related fatigue is centrally mediated; the

authors speculate that improvements in pain and fatigue reflect interactions between RA therapies and sensory neurons. This is a preview of subscription content, access via your institution

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about institutional subscriptions * Read our FAQs * Contact customer support RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Pain and depression cause

fatigue in patients with RA. _Nat Rev Rheumatol_ 2, 523 (2006). https://doi.org/10.1038/ncprheum0280 Download citation * Issue Date: October 2006 * DOI: https://doi.org/10.1038/ncprheum0280

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