Satb1 expression generates gene-expression profiles that promote breast tumor metastasis


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Access through your institution Buy or subscribe Han HJ _ et al_. (2008) SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. _Nature_ 452: 187–193


Gene-expression analyses of human breast cancer cell lines that are associated with a poor outcome have revealed characteristic expression patterns that can predict metastasis (or metastatic


risk), but how such gene-expression profiles confer metastatic potential is unclear. Han _ et al_. have described a genome organizer protein—SATB1—that when expressed in breast cancer cells


can establish a pattern of gene expression that is consistent with invasive behavior. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through


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breast tumor metastasis. _Nat Rev Clin Oncol_ 5, 364 (2008). https://doi.org/10.1038/ncponc1141 Download citation * Issue Date: July 2008 * DOI: https://doi.org/10.1038/ncponc1141 SHARE


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