The effects of hormone replacement therapy on renal function

ABSTRACT This Practice Point commentary discusses a study by Ahmed _ et al_. that evaluated the effects of hormone replacement therapy (conjugated estrogen alone, progestin alone or a

combination of progestin and conjugated estrogen) on renal function in elderly community-dwelling postmenopausal women. The authors found that oral estrogen therapy in this population was

associated with accelerated decline in kidney function over a 2-year period. In addition, the cumulative amount of estrogen intake was dose-dependently associated with the rate of renal

functional decline. This commentary highlights the human and experimental evidence suggesting that endogenous and exogenous estrogen affect renal function, and discusses the possible

beneficial or detrimental effects of hormone supplementation on kidney function. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in

* Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Silbiger SR and Neugarten J (2003) The role of gender in the progression of renal disease.

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Download references AUTHOR INFORMATION Author notes * Montefiore Medical Center, Department of Medicine, 111 East 210th Street, NW 6, Bronx, NY 10467, USA [email protected] AUTHORS AND

AFFILIATIONS * Member of the Division of Nephrology and the Director of the Internal Medicine Residency Program in the Department of Medicine at the Albert Einstein College of Medicine and

Montefiore Medical Center, S Silbiger is a Professor of Clinical Medicine, Bronx, NY, USA., Sharon Silbiger Authors * Sharon Silbiger View author publications You can also search for this

author inPubMed Google Scholar ETHICS DECLARATIONS COMPETING INTERESTS The author declares no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Silbiger, S. The effects of hormone replacement therapy on renal function. _Nat Rev Nephrol_ 5, 6–7 (2009). https://doi.org/10.1038/ncpneph0993 Download citation *

Received: 02 October 2008 * Accepted: 17 October 2008 * Published: 18 November 2008 * Issue Date: January 2009 * DOI: https://doi.org/10.1038/ncpneph0993 SHARE THIS ARTICLE Anyone you share

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