Is calcitriol treatment associated with improved survival in predialysis patients with chronic kidney disease?

ABSTRACT Observational studies have demonstrated that therapy with vitamin D analogs for treatment of secondary hyperparathyroidism is associated with improved survival in patients receiving

maintenance hemodialysis. This Practice Point commentary discusses an observational study of male predialysis patients with stage 3–5 chronic kidney disease performed by Kovesdy _ et al_.,

in which incidence rate ratios for all-cause mortality and combined death or dialysis initiation were found to be significantly lower in patients treated with calcitriol than in

non-calcitriol-treated patients. These data are compatible with many experimental data on the beneficial effect of vitamin D analogs on the cardiovascular system, renal structure and renal

function. Without data from randomized trials, however, it is still unclear whether calcitriol should be administered to all patients with chronic kidney disease, even those without

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our FAQs * Contact customer support REFERENCES * Kovesdy CP _ et al_. (2008) Association of activated vitamin D treatment and mortality in chronic kidney disease. _Arch Intern Med_ 168:

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cardiovascular disease. _Circulation_ 117: 503–511 Article  CAS  Google Scholar  Download references AUTHOR INFORMATION Author notes * Department of Geriatric Medicine and Nephrology, Osaka

University Graduate School of Medicine, Box A8, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan [email protected] AUTHORS AND AFFILIATIONS * T Hamano is an Assistant Professor in

the Department of Geriatric Medicine and Nephrology at Osaka University Graduate School of Medicine, Osaka, Japan., Takayuki Hamano Authors * Takayuki Hamano View author publications You

can also search for this author inPubMed Google Scholar ETHICS DECLARATIONS COMPETING INTERESTS The author declares no competing financial interests. RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hamano, T. Is calcitriol treatment associated with improved survival in predialysis patients with chronic kidney disease?. _Nat Rev Nephrol_

4, 416–417 (2008). https://doi.org/10.1038/ncpneph0857 Download citation * Received: 19 March 2008 * Accepted: 07 May 2008 * Published: 17 June 2008 * Issue Date: August 2008 * DOI:

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