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Miyamoto K et al. (2006) Unblinded pilot study of autologous transplantation of bone marrow mononuclear cells in patients with thromboangiitis obliterans. Circulation 114: 2679–2684
Therapeutic options for critical limb ischemia are limited, and patients are often unresponsive to drug therapy or unsuitable for percutaneous or surgical revascularization. Transplantation
of bone marrow mononuclear cells has previously been shown to have short-term clinical benefits for these 'no option' patients. Miyamoto et al. report on an uncontrolled, unblinded pilot
study of the long-term safety and efficacy of transplantation therapy in patients with thromboangiitis obliterans.
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