Metabolism regulates differentiation

A reverse genetic engineering approach identifies metabolic enzymes and their cellular pathways as potential regulators of myoblast differentiation. Targeting these metabolic nodes has

provocative implications for drug discovery and therapeutic efficacy. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution

ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Learn more Buy this article *

Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn

about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Madhani, H.D. & Fink, G.R. _Trends Cell Biol._ 8, 348–353 (1998). Article  CAS  Google Scholar 

* Gagiano, M., Bauer, F.F. & Pretorius, I.S. _FEMS Yeast Res._ 2, 433–470 (2002). CAS  PubMed  Google Scholar  * Bracha, A.L., Ramanathan, A., Huang, S., Ingber D.E. & Schreiber,

S.L. _Nat. Chem. Biol._ 6, 202–204 (2010). Article  CAS  Google Scholar  * White, K.P. et al. _Science_ 276, 114–117 (1997). Article  CAS  Google Scholar  * Wellen, K.E. et al. _Science_

324, 1076–1080 (2009). Article  CAS  Google Scholar  * Hatzivassiliou, G. et al. _Cancer Cell_ 8, 311–321 (2005). Article  CAS  Google Scholar  * Petrie, K., Zelent, A. & Waxman, S.

_Curr. Opin. Hematol._ 16, 84–91 (2009). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Timothy E. McGraw is in the Department of

Biochemistry, New York, New York, USA., Timothy E McGraw * Vivek Mittal is in the Departments of Cardiothoracic Surgery and Cell and Developmental Biology, Weill Medical College of Cornell

University, New York, New York, USA., Vivek Mittal Authors * Timothy E McGraw View author publications You can also search for this author inPubMed Google Scholar * Vivek Mittal View author

publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Timothy E McGraw or Vivek Mittal. ETHICS DECLARATIONS COMPETING INTERESTS The

authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE McGraw, T., Mittal, V. Metabolism regulates

differentiation. _Nat Chem Biol_ 6, 176–177 (2010). https://doi.org/10.1038/nchembio.324 Download citation * Issue Date: March 2010 * DOI: https://doi.org/10.1038/nchembio.324 SHARE THIS

ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard

Provided by the Springer Nature SharedIt content-sharing initiative