Caught by a sticky drug | Nature Chemical Biology

A new study reports THZ531 as a covalent CDK12/CDK13 inhibitor affecting transcription. Application of the compound in cells decreases transcription elongation of DNA damage response genes

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ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Fuda, N.J., Ardehali, M.B. & Lis, J.T. _Nature_

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55–62 (2016). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Dalibor Blazek is at the Central European Institute of Technology (CEITEC),

Masaryk University, Brno, Czech Republic., Dalibor Blazek Authors * Dalibor Blazek View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR

Correspondence to Dalibor Blazek. ETHICS DECLARATIONS COMPETING INTERESTS The author declares no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Blazek, D. Caught by a sticky drug. _Nat Chem Biol_ 12, 765–766 (2016). https://doi.org/10.1038/nchembio.2184 Download citation * Published: 20 September 2016 *

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