How to be quick on the uptake | Nature Chemical Biology

Stapled helices are promising compounds for inhibiting intracellular protein–protein interactions, but the discovery of peptides with the key property of cellular uptake has taken place

largely through trial and error. A new study defines physicochemical parameters for designing hydrocarbon-stapled helices with a greater likelihood of cellular uptake. Access through your

institution Buy or subscribe This is a preview of subscription content, access via your institution RELEVANT ARTICLES Open Access articles citing this article. * FBXW7 REGULATES DISC1

STABILITY VIA THE UBIQUITIN-PROTEOSOME SYSTEM * K Yalla * , C Elliott *  … G S Baillie _Molecular Psychiatry_ Open Access 20 July 2017 ACCESS OPTIONS Access through your institution

Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full

article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs *

Contact customer support REFERENCES * Andrews, M.J.I. & Tabor, A.B. _Tetrahedron_ 55, 11711–11743 (1999). Article  CAS  Google Scholar  * Harrison, R.S. et al. _Proc. Natl. Acad. Sci.

USA_ 107, 11686–11691 (2010). Article  CAS  Google Scholar  * Walensky, L.D. et al. _Science_ 305, 1466–1470 (2004). Article  CAS  Google Scholar  * Bird, G.H. et al. _Nat. Chem. Biol._ 12,

845–852 (2016). Article  CAS  Google Scholar  * Chu, Q. et al. _MedChemComm_ 6, 111–119 (2015). Article  CAS  Google Scholar  * Walensky, L.D. & Bird, G.H. _J. Med. Chem._ 57, 6275–6288

(2014). Article  CAS  Google Scholar  * Bock, J.E., Gavenonis, J. & Kritzer, J.A. _ACS Chem. Biol._ 8, 488–499 (2013). Article  CAS  Google Scholar  * Qian, Z. et al. _Biochemistry_ 55,

2601–2612 (2016). Article  CAS  Google Scholar  * Henriques, S.T. et al. _Chem. Biol._ 22, 1087–1097 (2015). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * Joshua Kritzer is at the Department of Chemistry, Tufts University, Medford, Massachusetts, USA., Joshua A Kritzer Authors * Joshua A Kritzer View author publications You can

also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Joshua A Kritzer. ETHICS DECLARATIONS COMPETING INTERESTS The author declares no competing

financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kritzer, J. How to be quick on the uptake. _Nat Chem Biol_ 12, 764–765 (2016).

https://doi.org/10.1038/nchembio.2183 Download citation * Published: 20 September 2016 * Issue Date: October 2016 * DOI: https://doi.org/10.1038/nchembio.2183 SHARE THIS ARTICLE Anyone you

share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the

Springer Nature SharedIt content-sharing initiative