Resolving the cadherin–f-actin connection

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Cadherin adhesion complexes have recently emerged as sensors of tissue tension that regulate key developmental processes. Super-resolution microscopy experiments now unravel the spatial


organization of the interface between cadherins and the actin cytoskeleton and reveal how vinculin, a central component in cadherin mechanotransduction, is regulated by mechanical and


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Contact customer support REFERENCES * Munjal, A. & Lecuit, T. _Development_ 141, 1789–1793 (2014). Article  CAS  Google Scholar  * Twiss, F. & de Rooij, J. _Cell Mol. Life Sci._ 70,


4101–4116 (2013). Article  CAS  Google Scholar  * Bertocchi, C. et al. _Nat. Cell Biol._ 19, 28–37 (2017). Article  CAS  Google Scholar  * Han, M. K. L. & de Rooij, J. _Trends Cell


Biol._ 26, 612–623 (2016). Article  Google Scholar  * Ladoux, B., Nelson, W. J., Yan, J. & Mège, R. M. _Integr. Biol._ 7, 1109–1119 (2015). Article  CAS  Google Scholar  * Yonemura, S.,


Wada, Y., Watanabe, T., Nagafuchi, A. & Shibata, M. _Nat. Cell Biol._ 12, 533–542 (2010). Article  CAS  Google Scholar  * Kanchanawong, P. et al. _Nature_ 468, 580–584 (2010). Article 


CAS  Google Scholar  * Bays, J. L. et al. _J. Cell Biol._ 205, 251–263 (2014). Article  CAS  Google Scholar  * Auernheimer, V. et al. _J. Cell Sci._ 128, 3435–3443 (2015). Article  CAS 


Google Scholar  * Atherton, P., Stutchbury, B., Jethwa, D. & Ballestrem, C. _Exp. Cell Res._ 343, 21–27 (2016). Article  CAS  Google Scholar  * Pasapera, A. M., Schneider, I. C.,


Rericha, E., Schlaepfer, D. D. & Waterman, C. M. _J. Cell Biol._ 188, 877–890 (2010). Article  CAS  Google Scholar  * Ladoux, B. et al. _Biophys. J._ 98, 534–542 (2010). Article  CAS 


Google Scholar  * Kris, A. S., Kamm, R. D. & Sieminski, A. L. _Biochem. Biophys. Res. Commun._ 375, 134–138 (2008). Article  CAS  Google Scholar  * Leerberg, J. M. et al. _Curr. Biol._


24, 1689–1699 (2014). Article  CAS  Google Scholar  * Huveneers, S. et al. _J. Cell Biol._ 196, 641–652 (2012). Article  CAS  Google Scholar  * Oldenburg, J. et al. _Sci. Rep._ 5, 17225


(2015). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Mitchell K. L. Han and Johan de Rooij are at the Molecular Cancer Research, Center for


Molecular Medicine, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands, Mitchell K. L. Han & Johan de Rooij Authors * Mitchell K. L. Han View author publications You


can also search for this author inPubMed Google Scholar * Johan de Rooij View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR


Correspondence to Johan de Rooij. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS


ARTICLE CITE THIS ARTICLE Han, M., de Rooij, J. Resolving the cadherin–F-actin connection. _Nat Cell Biol_ 19, 14–16 (2017). https://doi.org/10.1038/ncb3457 Download citation * Published: 23


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