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Access through your institution Buy or subscribe Labrijn _et al_. reply: Our papers test the hypothesis of IgG4 Fab-arm exchange1,2. In a series of _in vitro_ and _in vivo_ experiments, we


provide convincing experimental evidence for the occurrence of Fab-arm exchange and show that this mechanism represents an intrinsic activity of IgG4 antibodies that affects treatment with


IgG4-based therapeutics in patients. Broug _et al_. criticize our approach and suggest that we are reiterating previous insights. Surely, however, Broug _et al_. understand that we are


employing the time-honored approach of hypothesis-driven research. Thus, a hypothesis should not be accepted until rigorous testing shows it to be true, which then leads to novel hypotheses.


IgG4 Fab-arm exchange thereby has only recently become scientific fact1,2. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your


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our FAQs * Contact customer support REFERENCES * Labrijn, A.F. et al. _Nat. Biotechnol._ 27, 767–771 (2009). Article  CAS  PubMed  Google Scholar  * van der Neut Kolfschoten, M. et al.


_Science_ 317, 1554–1557 (2007). Article  CAS  PubMed  Google Scholar  * Burton, D.R. & Wilson, I.A. _Science_ 317, 1507–1508 (2007). Article  CAS  PubMed  Google Scholar  * Hansen, K.


et al. _Mol. Immunol._ 46, 3269–3277 (2009). Article  CAS  PubMed  Google Scholar  * De Rubertis, F., Fleck, R. & Lanthaler, W. _Nat. Biotechnol._ 27, 595–597 (2009). CAS  Google Scholar


  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Genmab, Utrecht, The Netherlands Aran F Labrijn, Janine Schuurman, Jan G J van de Winkel & Paul W H I Parren Authors *


Aran F Labrijn View author publications You can also search for this author inPubMed Google Scholar * Janine Schuurman View author publications You can also search for this author inPubMed 


Google Scholar * Jan G J van de Winkel View author publications You can also search for this author inPubMed Google Scholar * Paul W H I Parren View author publications You can also search


for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Paul W H I Parren. ETHICS DECLARATIONS COMPETING INTERESTS A.F.L., J.S., J.G.J.v.d.W. and P.W.H.I.P. are Genmab


employees and own warrants and/or stock. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Labrijn, A., Schuurman, J., van de Winkel, J. _et al._ Reply to


Fab-arm exchange. _Nat Biotechnol_ 28, 125–126 (2010). https://doi.org/10.1038/nbt0210-125 Download citation * Issue Date: February 2010 * DOI: https://doi.org/10.1038/nbt0210-125 SHARE


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