Experimental models of arteriogenesis: differences and implications

ABSTRACT Cardiovascular and cerebrovascular disease represent the two most common causes of mortality and morbidity in western countries, and the treatment for these is generally by the

mechanical restoration of blood flow in the affected tissues. Stimulation of collateral artery growth (arteriogenesis) provides a potential alternative option for the treatment of patients

suffering from occlusive artery disease. Therefore, researchers have established several angiogenesis and arteriogenesis animal models to investigate basic mechanisms and pharmacological

modulation of collateral artery growth. The authors highlight the most important aspects of vascular growth, discuss different methods and techniques for examining the process, and review

the advantages and disadvantages associated with the animal models available for studying this phenomenon. Access through your institution Buy or subscribe This is a preview of subscription

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customer support SIMILAR CONTENT BEING VIEWED BY OTHERS CORONARY VESSEL FORMATION IN DEVELOPMENT AND DISEASE: MECHANISMS AND INSIGHTS FOR THERAPY Article 25 June 2020 MODELING EARLY STAGE

ATHEROSCLEROSIS IN A PRIMARY HUMAN VASCULAR MICROPHYSIOLOGICAL SYSTEM Article Open access 27 October 2020 EXPERIMENTAL MURINE ARTERIOVENOUS FISTULA MODEL TO STUDY RESTENOSIS AFTER

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178–185 (2003). Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Experimental Cardiology, UMC, University of Utrecht, The Netherlands

Imo E. Hoefer MD, PhD * Department of Cardiology, AMC, University of Amsterdam, The Netherlands Niels van Royen MD, PhD * BioVisioN AG, Medical Research, Hannover, 30625, Germany Marco M.

Jost PhD Authors * Imo E. Hoefer MD, PhD View author publications You can also search for this author inPubMed Google Scholar * Niels van Royen MD, PhD View author publications You can also

search for this author inPubMed Google Scholar * Marco M. Jost PhD View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to

Imo E. Hoefer MD, PhD. ETHICS DECLARATIONS COMPETING INTERESTS Hoefer and van Royen are shareholders of Perfusion Technologies GmbH, Freiburg, Germany. RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hoefer, I., van Royen, N. & Jost, M. Experimental models of arteriogenesis: differences and implications. _Lab Anim_ 35, 36–44 (2006).

https://doi.org/10.1038/laban0206-36 Download citation * Received: 23 December 2004 * Accepted: 22 August 2005 * Issue Date: February 2006 * DOI: https://doi.org/10.1038/laban0206-36 SHARE

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