Bronchopulmonary dysplasia and pulmonary hypertension: a meta-analysis

ABSTRACT OBJECTIVE: Pulmonary hypertension (PH) is a complication of bronchopulmonary dysplasia (BPD) but the true impact of PH in patients with BPD remains unclear. We sought to

systematically review and meta-analyze incidence of PH in BPD and compare clinical outcomes of BPD patients with PH to those without PH in preterm infants. STUDY DESIGN: Medline, Embase,

PsychINFO and CINAHL were searched from January 2000 through December 2015. Cohort, case–control and randomized studies were included. Case-reports, case-series and letters to editors and

studies with high risk of bias were excluded. Study design, inclusion/exclusion criteria, diagnostic criteria for BPD and PH and outcomes were extracted independently by two co-authors.

RESULTS: The pooled incidence of PH in patients with BPD (any severity) was 17% (95% confidence interval (CI) 12 to 21; 7 studies) and 24% (95% CI 17 to 30; 9 studies) in moderate-severe

BPD. Patients with BPD have higher unadjusted odds of developing PH compared to those without BPD (odds ratio (OR) 3.00; 95% CI 1.18 to 7.66; 4 studies). Patients with BPD and PH were at

higher odds of mortality (OR 5.29; 95% CI 2.07 to 13.56; 3 studies) compared with BPD without PH, but there was no significant difference in duration of initial hospitalization, duration of

supplemental oxygen requirement or need for home oxygen. No studies included in this review reported on long-term pulmonary or neurodevelopmental outcomes. CONCLUSIONS: PH occurs in one out

of 4 to 5 preterm neonates with BPD. Patients with BPD and PH may have higher odds of mortality; however, there is urgent need for high quality studies that control for confounders and

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Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS OUTCOMES OF INFANTS AND CHILDREN WITH BRONCHOPULMONARY DYSPLASIA-ASSOCIATED PULMONARY HYPERTENSION WHO

REQUIRED HOME VENTILATION Article 24 August 2024 PULMONARY HYPERTENSION IN BRONCHOPULMONARY DYSPLASIA Article Open access 10 June 2020 RISK FACTORS OF EARLY PULMONARY HYPERTENSION AND ITS

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registration and registration number: PROSPERO CRD42016042104. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, McMaster University, Hamilton, ON, Canada G Al-Ghanem, 

L Banfield, S el Helou, C Fusch & A Mukerji * Department of Pediatrics, University of Toronto, Toronto, ON, Canada P Shah * Department of Pediatrics, University of Calgary, Calgary, AB,

Canada S Thomas Authors * G Al-Ghanem View author publications You can also search for this author inPubMed Google Scholar * P Shah View author publications You can also search for this

author inPubMed Google Scholar * S Thomas View author publications You can also search for this author inPubMed Google Scholar * L Banfield View author publications You can also search for

this author inPubMed Google Scholar * S el Helou View author publications You can also search for this author inPubMed Google Scholar * C Fusch View author publications You can also search

for this author inPubMed Google Scholar * A Mukerji View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to A Mukerji.

ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. ADDITIONAL INFORMATION Data from this research were presented at Pediatric Academic Societies, San Diego

2016. Supplementary Information accompanies the paper on the Journal of Perinatology website SUPPLEMENTARY INFORMATION SUPPLEMENTARY FILE 1 (DOCX 18 KB) SUPPLEMENTARY FILE 2 (DOCX 17 KB)

SUPPLEMENTARY FILE 3 (DOCX 74 KB) SUPPLEMENTARY FILE 4 (DOCX 23 KB) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Al-Ghanem, G., Shah, P., Thomas, S.

_et al._ Bronchopulmonary dysplasia and pulmonary hypertension: a meta-analysis. _J Perinatol_ 37, 414–419 (2017). https://doi.org/10.1038/jp.2016.250 Download citation * Received: 12

October 2016 * Revised: 22 November 2016 * Accepted: 28 November 2016 * Published: 12 January 2017 * Issue Date: April 2017 * DOI: https://doi.org/10.1038/jp.2016.250 SHARE THIS ARTICLE

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