Cytokine changes in newborns with therapeutic hypothermia after hypoxic ischemic encephalopathy

ABSTRACT OBJECTIVE: This study aimed to examine changes in cytokines according to therapeutic hypothermia (TH) for newborn hypoxic ischemic encephalopathy (HIE). STUDY DESIGN: We studied 20

neonates who were admitted with a diagnosis of HIE in the neonatal intensive care unit. Cytokine concentration assay was carried out for neonates (_n_=12) who received TH and neonates

(_n_=8) who were not treated with hypothermia by collecting blood sample at 12, 48 and 120 h after birth. RESULTS: At 48 h after birth, interleukin (IL)-6 in the normothermia group was

higher than that in the hypothermia group (_P_=0.010). At 48 h after birth, IL-10 was higher in the hypothermia group than in the normothermia group (_P_=0.038). CONCLUSION: This study

confirmed that TH performs a role in the prevention of inflammatory process by way of maintaining proinflammatory cytokine IL-6 at low levels and anti-inflammatory cytokines IL-10 at high

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support SIMILAR CONTENT BEING VIEWED BY OTHERS BLOOD BIOMARKERS FOR NEONATAL HYPOXIC–ISCHEMIC ENCEPHALOPATHY IN THE PRESENCE AND ABSENCE OF SENTINEL EVENTS Article 06 October 2020 SERIAL

PLASMA BIOMARKERS OF BRAIN INJURY IN INFANTS WITH NEONATAL ENCEPHALOPATHY TREATED WITH THERAPEUTIC HYPOTHERMIA Article 02 March 2021 HYPOTHERMIA IS NOT THERAPEUTIC IN A NEONATAL PIGLET MODEL

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supernatant separation and blood sample storage. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, The Catholic University of Korea, Seoul St Mary’s Hospital, Seoul,

Republic of Korea C J Moon, Y A Youn, S K Yum & I K Sung Authors * C J Moon View author publications You can also search for this author inPubMed Google Scholar * Y A Youn View author

publications You can also search for this author inPubMed Google Scholar * S K Yum View author publications You can also search for this author inPubMed Google Scholar * I K Sung View author

publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to I K Sung. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no

conflict of interest. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Moon, C., Youn, Y., Yum, S. _et al._ Cytokine changes in newborns with therapeutic

hypothermia after hypoxic ischemic encephalopathy. _J Perinatol_ 36, 1092–1096 (2016). https://doi.org/10.1038/jp.2016.132 Download citation * Received: 21 April 2016 * Revised: 08 July 2016

* Accepted: 11 July 2016 * Published: 01 September 2016 * Issue Date: December 2016 * DOI: https://doi.org/10.1038/jp.2016.132 SHARE THIS ARTICLE Anyone you share the following link with

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