Fetal growth restriction and pulmonary hypertension in premature infants with bronchopulmonary dysplasia

ABSTRACT OBJECTIVE: To identify the association between birth weight (BW)-for-gestational age (GA) and pulmonary hypertension (PHTN) at 36 weeks in infants with moderate–severe

bronchopulmonary dysplasia (BPD). STUDY DESIGN: In this retrospective cohort study, we followed 138 premature infants (⩽28 weeks) with moderate and severe BPD (National Institutes of Health

consensus definition) born at Prentice Women’s Hospital between 2005 and 2009. BW percentiles were calculated using the Fenton growth curve for premature infants. PHTN was determined using a

standardized algorithm of echocardiogram review at 36 weeks. Logistic regression was used to evaluate the associations between BW percentile subgroups and PHTN, taking into account

antenatal and neonatal factors that were related to PHTN. RESULT: PHTN was associated with small BW-for-GA, ranging from thresholds of <10th to <25th percentile (_P_<0.001). These

associations remained significant when comparing BW <25th percentile to the reference group (50 to 89th percentile); after adjustment for GA, gender, multiple gestation, race/ethnicity

(odds ratio (OR)=4.2; 95% confidence interval (CI)=1.5, 12.1); and after further adjustment for maternal vascular disease, intrauterine infection, oligohydramnios and relevant postnatal

factors (OR=5.7; 95% CI=1.5, 21.2). Longitudinal follow-up of this cohort showed a trend toward higher morbidity and death among PHTN infants with BW <25th percentile. CONCLUSION:

BW-for-GA is an important predictor of PHTN in premature infants with moderate–severe BPD. Our findings contribute to the growing evidence supporting fetal mechanisms of later onset

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our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS LONG-TERM IMPACT OF LATE PULMONARY HYPERTENSION REQUIRING MEDICATION IN EXTREMELY PRETERM INFANTS WITH SEVERE

BRONCHOPULMONARY DYSPLASIA Article Open access 15 April 2024 EARLY PULMONARY HYPERTENSION IS A RISK FACTOR FOR BRONCHOPULMONARY DYSPLASIA-ASSOCIATED LATE PULMONARY HYPERTENSION IN EXTREMELY

PRETERM INFANTS Article Open access 27 May 2021 EARLY CARDIAC FUNCTION AND DEATH, SEVERE BRONCHOPULMONARY DYSPLASIA AND PULMONARY HYPERTENSION IN EXTREMELY PRETERM INFANTS Article 19

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  Google Scholar  Download references ACKNOWLEDGEMENTS This project was supported by NHLBI Grant K23 HL093302 (PI: Mestan). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of

Pediatrics, Division of Neonatology, Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, USA J Check, N Porta, R Steinhorn & K K

Mestan * Department of Pediatrics, Division of Cardiology, Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, USA N Gotteiner *

Department of Pediatrics, Mary Ann and J Milburn Smith Child Health Research Program, Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL,

USA X Liu * Department of Obstetrics and Gynecology, Divisions of Maternal Fetal Medicine and Reproductive Biology Research, Northwestern University Feinberg School of Medicine, Chicago, IL,

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author inPubMed Google Scholar * K K Mestan View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to K K Mestan. ETHICS

DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Check, J., Gotteiner, N.,

Liu, X. _et al._ Fetal growth restriction and pulmonary hypertension in premature infants with bronchopulmonary dysplasia. _J Perinatol_ 33, 553–557 (2013).

https://doi.org/10.1038/jp.2012.164 Download citation * Received: 17 April 2012 * Revised: 24 October 2012 * Accepted: 10 December 2012 * Published: 17 January 2013 * Issue Date: July 2013 *

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * intrauterine growth restriction * small-for-gestational

age * pulmonary vascular disease * preterm birth