Cardiovascular impacts and micro-environmental exposure factors associated with continuous personal pm2. 5 monitoring

ABSTRACT The US Environmental Protection Agency’s (US EPA) Detroit Exposure and Aerosol Research Study (DEARS) has provided extensive data on human exposures to a wide variety of air

pollutants and their impact on human health. Previous analyses in the DEARS revealed select cardiovascular (CV) health outcomes such as increase in heart rate (HR) associated with hourly

based continuous personal fine particulate matter (PM2.5) exposures in this adult, non-smoking cohort. Examination of time activity diary (TAD), follow-up questionnaire (FQ) and the

continuous PM2.5 personal monitoring data provided the means to more fully examine the impact of discreet human activity patterns on personal PM2.5 exposures and changes in CV outcomes. A

total of 329 343 min-based PM2.5 personal measurements involving 50 participants indicated that ∼75% of these total events resulted in exposures <35 _μ_g/m3. Cooking and car-related

events accounted for nearly 10% of the hourly activities that were identified with observed peaks in personal PM2.5 exposures. In-residence cooking often resulted in some of the highest

incidents of 1 min exposures (33.5–17.6 _μ_g/m3), with average peaks for such events in excess of 209 _μ_g/m3. PM2.5 exposure data from hourly based personal exposure activities (for

example,, cooking, cleaning and household products) were compared with daily CV data from the DEARS subject population. A total of 1300 hourly based lag risk estimates associated with

changes in brachial artery diameter and flow-mediated dilatation (BAD and FMD, respectively), among others, were defined for this cohort. Findings indicate that environmental tobacco smoke

(ETS) exposures resulted in significant HR changes between 3 and 7 h following the event, and exposure to smells resulted in increases in BAD on the order of 0.2–0.7 mm/_μ_g/m3. Results

demonstrate that personal exposures may be associated with several biological responses, sometimes varying in degree and direction in relation to the extent of the exposure. Access through

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CONTENT BEING VIEWED BY OTHERS USING TIME-RESOLVED MONITOR WEARING DATA TO STUDY THE EFFECT OF CLEAN COOKING INTERVENTIONS ON PERSONAL AIR POLLUTION EXPOSURES Article 23 October 2022

EVALUATION OF INDOOR PM2.5 CONCENTRATIONS IN A NATIVE AMERICAN COMMUNITY: A PILOT STUDY Article 04 August 2021 PREDICTION OF PERSONAL EXPOSURE TO PM2.5 IN MOTHER-CHILD PAIRS IN RURAL GHANA

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ACKNOWLEDGEMENTS The US Environmental Protection Agency through its Office of Research and Development funded and conducted the research described here under contract 68-D-00-012 (RTI

International), EP-D-04-068 (Battelle Columbus Laboratory), 68-D-00-206 and EP-05-D-065 (Alion Science and Technology). It has been subjected to Agency review and approved for publication.

Mention of trade names or commercial products does not constitute an endorsement or recommendation for use. The US EPA acknowledges the staffs of Alion Science and Technology for preparation

of sampling media and RTI International for overseeing field data collections. We thank the DEARS cohort for their participation. AUTHOR INFORMATION Author notes * Davyda Hammond: Currently

affiliated with Germanna Community College, Fredericksburg, VA, USA. AUTHORS AND AFFILIATIONS * US Environmental Protection Agency, MD E-205-04, Research Triangle Park, NC, USA Davyda

Hammond, Carry Croghan & Ron Williams * Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada Hwashin Shin & Richard Burnett * Division of

Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA Robert Bard & Robert D Brook Authors * Davyda Hammond View author publications You can also search for this author

inPubMed Google Scholar * Carry Croghan View author publications You can also search for this author inPubMed Google Scholar * Hwashin Shin View author publications You can also search for

this author inPubMed Google Scholar * Richard Burnett View author publications You can also search for this author inPubMed Google Scholar * Robert Bard View author publications You can also

search for this author inPubMed Google Scholar * Robert D Brook View author publications You can also search for this author inPubMed Google Scholar * Ron Williams View author publications

You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Ron Williams. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of

interest. All human interactions in the collection of the data presented were approved by Institutional Review Boards and all Human Subjects Approving Offices associated with the study.

ADDITIONAL INFORMATION Supplementary Information accompanies the paper on the Journal of Exposure Science and Environmental Epidemiology website SUPPLEMENTARY INFORMATION SUPPLEMENTARY

INFORMATION (DOC 53 KB) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hammond, D., Croghan, C., Shin, H. _et al._ Cardiovascular impacts and

micro-environmental exposure factors associated with continuous personal PM2.5 monitoring. _J Expo Sci Environ Epidemiol_ 24, 337–345 (2014). https://doi.org/10.1038/jes.2013.46 Download

citation * Received: 23 August 2012 * Revised: 12 March 2013 * Accepted: 28 April 2013 * Published: 28 August 2013 * Issue Date: July 2014 * DOI: https://doi.org/10.1038/jes.2013.46 SHARE

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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * DEARS * exposure factors * cardiovascular health outcomes