Miuraenamides a and b, novel antimicrobial cyclic depsipeptides from a new slightly halophilic myxobacterium: taxonomy, production, and biological properties

ABSTRACT A slightly halophilic myxobacterial strain, SMH-27-4, was isolated from nearshore soil and shown to belong to a new myxobacterium genus based on phylogenetic analysis. This

slowly-growing myxobacterium produced the novel antibiotic depsipeptides miuraenamides A and B. Their physico-chemical properties and molecular formulas, C34H42N3O7Br and C34H42N3O7I, were

determined. Miuraenamides A exhibited potent and selective inhibition against a phytopathogenic microorganism, _Phytophthora_ sp., and moderate inhibition against some fungi and yeasts, but

was ineffective against bacteria. Both of the metabolites inhibited NADH oxidase at IC50 values of 50 μM, suggesting, like β-methoxyacrylate-type antibiotics, the electron transfer system of

the mitochondrial respiratory chain as the cellular target. SIMILAR CONTENT BEING VIEWED BY OTHERS SUERTIDES A–C: SELECTIVE ANTIBACTERIAL CYCLIC HEXAPEPTIDES FROM _AMYCOLATOPSIS_ SP.

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Microbiology Group, Institute of Life Sciences, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki, 210-8681, Japan Takashi Iizuka, Ryosuke Fudou & Yasuko Jojima * Faculty of

Textile Science and Technology, Shinshu University, 3-15-1 Tsuneda, Ueda, 386-8567, Japan Sumie Ogawa & Shigeru Yamanaka * Graduate School of Bioagricultural Sciences, Nagoya University,

Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan Yasutaka Inukai & Makoto Ojika Authors * Takashi Iizuka View author publications You can also search for this author inPubMed Google

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this author inPubMed Google Scholar * Yasutaka Inukai View author publications You can also search for this author inPubMed Google Scholar * Makoto Ojika View author publications You can

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Iizuka, T., Fudou, R., Jojima, Y. _et al._ Miuraenamides A and B, Novel Antimicrobial Cyclic Depsipeptides from a New Slightly Halophilic Myxobacterium: Taxonomy, Production, and Biological

Properties. _J Antibiot_ 59, 385–391 (2006). https://doi.org/10.1038/ja.2006.55 Download citation * Received: 16 May 2006 * Accepted: 01 July 2006 * Issue Date: 01 July 2006 * DOI:

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available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * myxobacterium * antibiotics * depsipeptides * polyketide *

electron transport inhibitor