Metabolic inflexibility of white and brown adipose tissues in abnormal fatty acid partitioning of type 2 diabetes

ABSTRACT Type 2 diabetes (T2D) is characterized by a general dysregulation of postprandial energy substrate partitioning. Although classically described in regard to glucose metabolism, it

is now evident that metabolic inflexibility of plasma lipid fluxes is also present in T2D. The organ that is most importantly involved in the latter metabolic defect is the white adipose

tissue (WAT). Both catecholamine-induced nonesterified fatty acid mobilization and insulin-stimulated storage of meal fatty acids are impaired in many WAT depots of insulin-resistant

individuals. Novel molecular imaging techniques now demonstrate that these defects are linked to increased dietary fatty acid fluxes toward lean organs and myocardial dysfunction in humans.

Recent findings also demonstrate functional abnormalities of brown adipose tissues in T2D, thus suggesting that a generalized adipose tissue dysregulation of energy storage and dissipation

may be at play in the development of lean tissue energy overload and lipotoxicity. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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ACKNOWLEDGEMENTS SML is the recipient of a Canadian Diabetes Association doctoral studentship. ACC is the recipient of the CIHR-GSK Chair in Diabetes. AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * Department of Medicine, Division of Endocrinology, Centre Hospitalier Université de Sherbrooke, Sherbrooke, Québec, Canada T Grenier-Larouche, S M Labbé, C Noll & A C

Carpentier * Centre de recherche de l’Institut de cardiologie et de pneumologie de Québec, Université Laval Québec, Québec City, Québec, Canada D Richard Authors * T Grenier-Larouche View

author publications You can also search for this author inPubMed Google Scholar * S M Labbé View author publications You can also search for this author inPubMed Google Scholar * C Noll View

author publications You can also search for this author inPubMed Google Scholar * D Richard View author publications You can also search for this author inPubMed Google Scholar * A C

Carpentier View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to A C Carpentier. ETHICS DECLARATIONS COMPETING INTERESTS

The authors declare no conflict of interest. ADDITIONAL INFORMATION This article was published as part of a supplement funded with an unrestricted educational contribution from Desjardins

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and brown adipose tissues in abnormal fatty acid partitioning of type 2 diabetes. _Int J Obes Supp_ 2 (Suppl 2), S37–S42 (2012). https://doi.org/10.1038/ijosup.2012.21 Download citation *

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KEYWORDS * fatty acids * white adipose tissues * brown adipose tissues * catecholamine resistance * insulin resistance * nonshivering thermogenesis