Comprehensive evaluation of genetic and environmental factors influencing the plasma lipoprotein-associated phospholipase a2 activity in a japanese population

ABSTRACT The lipoprotein-associated phospholipase A2 (Lp-PLA2) metabolizes oxidized phospholipids, generating lysophosphatidylcholine. The activity of the enzyme is known to be influenced

largely by a single-nucleotide polymorphism, G994T, in the Lp-PLA2 gene. Interestingly, this polymorphism is much more prevalent in Japanese than Caucasians. The purpose of the current study

was to evaluate the effects of the G994T, several environmental factors, and their interactions on the Lp-PLA2 activity in a large Japanese cohort. Participants (1,110 males and 908

females) of a health-screening examination were recruited for this study. Genotyping of the G994T was done using allele-specific polymerase chain reaction (PCR). The Lp-PLA2 activity was

measured using commercial kits. The minor allele (994T) frequency of the polymorphism was 0.17 in this study, which was consistent with previous reports. According to the multivariate linear

regression analysis, the G994T was the most potent factor influencing the enzyme activity (standardized _β_=0.76), followed by the low-density lipoprotein cholesterol (LDL-C) level

(standardized _β_=0.32) and the sex (standardized _β_=0.13). The LDL-C level showed a significant interaction with the G994T genotype. By contrast, no significant interaction was observed

between the LDL-C level and the sex. These observations should provide useful information for future clinical and epidemiological evaluations of the Lp-PLA2 activity in cardiovascular

diseases in Japanese. SIMILAR CONTENT BEING VIEWED BY OTHERS ASSOCIATIONS OF GENETIC VARIANTS OF LYSOPHOSPHATIDYLCHOLINE METABOLIC ENZYMES WITH LEVELS OF SERUM LIPIDS Article 02 May 2021

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CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Epidemiology, Public Health College, Harbin Medical University, Harbin, P.R. China

Shao-Yan Zhang & Bin-You Wang * Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan Shao-Yan Zhang & Toru Nabika * Central Clinical Laboratory,

Shimane University Hospital, Izumo, Japan Hiroshi Shibata, Kenji Karino & Junichi Masuda * Third Department of Internal Medicine, Shimane University School of Medicine, Izumo, Japan

Shotai Kobayashi Authors * Shao-Yan Zhang View author publications You can also search for this author inPubMed Google Scholar * Hiroshi Shibata View author publications You can also search

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AUTHOR Correspondence to Toru Nabika. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Zhang, SY., Shibata, H., Karino, K. _et al._ Comprehensive

Evaluation of Genetic and Environmental Factors Influencing the Plasma Lipoprotein-Associated Phospholipase A2 Activity in a Japanese Population. _Hypertens Res_ 30, 403–409 (2007).

https://doi.org/10.1291/hypres.30.403 Download citation * Received: 12 October 2006 * Accepted: 26 December 2006 * Issue Date: 01 May 2007 * DOI: https://doi.org/10.1291/hypres.30.403 SHARE

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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * lipoprotein-associated phospholipase A2 * platelet-activating factor acetylhydrolase * single

nucleotide polymorphisms * gene-environment interaction * oxidative stress