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ABSTRACT The association between HLA-A29 and birdshot chorioretinopathy is the strongest association between HLA and disease ever described. The determination of HLA-A29 is therefore of
diagnostic significance. The association between HLA-B27 and acute anterior uveitis (AAU) is much weaker. However, it is evident that B27+AAU is clinically different from B27−AAU. Half of
the B27+AAU patients have or will have ankylosing spondylitis or Reiter's syndrome. The determination of HLA-B27 is therefore of clinical significance and should be determined in each
case of AAU. The B27+ patients should be referred to a rheumatologist. The determination of HLA-Bw51 is of limited but significant diagnostic value for the diagnosis of Behçet's disease
in countries around the Mediterranean Sea or Japan. In Northern Europe HLA-Bw51 determination will not give much practical information. The structure and function of HLA class I molecules
is now known. It is probable that HLA-A29 and HLA-B27 molecules are directly involved in the pathogenesis of respectively birdshot chorioretinopathy and AAU SIMILAR CONTENT BEING VIEWED BY
OTHERS LONG TERM COMPLICATIONS AND VISION LOSS IN HLA-B27 UVEITIS Article Open access 29 August 2022 THE INCIDENCE, PRESENTING CLINICAL FINDINGS AND TREATMENT PATTERNS OF BIRDSHOT
RETINOCHOROIDITIS IN A HIGH-PREVALENCE REGION: FINDINGS FROM NORTHERN IRELAND, ENGLAND AND WALES Article Open access 10 February 2023 PROGRESS IN THE GENETICS OF UVEITIS Article Open access
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Molecular mimicry in HLA-B27 related arthritis. _Ann Inern Med_ 1989, 111: 581–91. Article CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Netherlands
Ophthalmic Research Institute and Central Laboratory for Bloodtransfusion Service, Amsterdam T E W Feltkamp Authors * T E W Feltkamp View author publications You can also search for this
author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Feltkamp, T. Ophthalmological significance of HLA associated uveitis.
_Eye_ 4, 839–844 (1990). https://doi.org/10.1038/eye.1990.133 Download citation * Issue Date: 01 November 1990 * DOI: https://doi.org/10.1038/eye.1990.133 SHARE THIS ARTICLE Anyone you share
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