Ophthalmological significance of hla associated uveitis

ABSTRACT The association between HLA-A29 and birdshot chorioretinopathy is the strongest association between HLA and disease ever described. The determination of HLA-A29 is therefore of

diagnostic significance. The association between HLA-B27 and acute anterior uveitis (AAU) is much weaker. However, it is evident that B27+AAU is clinically different from B27−AAU. Half of

the B27+AAU patients have or will have ankylosing spondylitis or Reiter's syndrome. The determination of HLA-B27 is therefore of clinical significance and should be determined in each

case of AAU. The B27+ patients should be referred to a rheumatologist. The determination of HLA-Bw51 is of limited but significant diagnostic value for the diagnosis of Behçet's disease

in countries around the Mediterranean Sea or Japan. In Northern Europe HLA-Bw51 determination will not give much practical information. The structure and function of HLA class I molecules

is now known. It is probable that HLA-A29 and HLA-B27 molecules are directly involved in the pathogenesis of respectively birdshot chorioretinopathy and AAU SIMILAR CONTENT BEING VIEWED BY

OTHERS LONG TERM COMPLICATIONS AND VISION LOSS IN HLA-B27 UVEITIS Article Open access 29 August 2022 THE INCIDENCE, PRESENTING CLINICAL FINDINGS AND TREATMENT PATTERNS OF BIRDSHOT

RETINOCHOROIDITIS IN A HIGH-PREVALENCE REGION: FINDINGS FROM NORTHERN IRELAND, ENGLAND AND WALES Article Open access 10 February 2023 PROGRESS IN THE GENETICS OF UVEITIS Article Open access

04 April 2022 ARTICLE PDF REFERENCES * Feltkamp TEW : New views on B27 associated diseases. _Neth J Med_ 1989, 35: 119–22. CAS  PubMed  Google Scholar  * Feltkamp TEW : HLA and eye diseases.

_J Head and Neck Pathol_ 1990, 9: 21–6. Google Scholar  * Tirawi JL and Terasaki PI : _HLA and disease associations._ New York, Springer Verlag, 1985: * Priem HA, Kijlstra A, Nones L,

Baarsma GS, De Laey JJ, Oosterhuis JA : HLA typing in birdshot chorioretinopathy. _Am J Ophthalmol_ 1988, 105: 182–5. Article  CAS  Google Scholar  * Suchman AL and Dolan JG : Odds and

likelihood ratios. In: Grimer PF, Panzer RJ, Greenland P (eds). _Clinical diagnosis and the laboratory._ Year Book Medical Publishers, Chicago 1986: 36. * Fagan TJ : Nomogram for

Bayes's theorem. _N Engl J Med_ 1975, 293: 257. CAS  PubMed  Google Scholar  * Feltkamp TEW : HLA and uveitis. _Int Ophthalmol_ 1990 (in press). * Rothova A, Van Veenendaal WG, Linssen

A, Glasius E, Kijlstra A, de Jong PTVM : Clinical features of acute anterior uveitis. _Am J Ophthalmol_ 1987, 103: 137–45. Article  CAS  Google Scholar  * Saari KM : Acute anterior uveitis.

In: Saari KM (ed). _Uveitis update_, Amstedam, 1984: 91–5. * Linssen A, Dekker-Saeys AJ, Dijkstra PF, Rothova A, Kruit PJ, Bakker M, Kijlstra A, Feltkamp TEW : The use of HLA-B27 as a

diagnostic and prognostic aid in acute anterior uveitis (AAU) in the Netherlands. _Doc Ophthalmol_ 1987, 64: 217–23. Article  Google Scholar  * Linssen A and Feltkamp TEW : B27 positive

diseases versus B27 negative diseases. _Ann Rheum Dis_ 1988, 47: 431–9. Article  CAS  Google Scholar  * Ohno S : HLA and endogenous uveitis. In: Belfort RR, Petrilli AMN, Nussenblatt R

(eds). _World uveitis symposium._ Sao Paulo, Livraria Roca 1989: 119–27. * Linssen A : Acute anterior uveitis, ankylosing spondylitis and HLA-B27. Thesis, The Hague, Opmeer Offset B.V.,

1987. * Derhaag PJFM, Linssen A, Broekema N, de Waal LP, Feltkamp TEW : A family study of the inheritance of HLA-B27 positive acute anterior uveitis. _Am J Ophthalmol_ 1988, 105: 603–6.

Article  CAS  Google Scholar  * Derhaag PJFM, van der Horst AR, de Waal LP, Feltkamp TEW : HLA-B27+ acute anterior uveitis and other antigens of the major histocompatibility complex. _Invest

Ophthalmol Vis Sci_ 1989, 30: 2160–4. CAS  PubMed  Google Scholar  * Linssen A, Rothova A, Broekema N, Derhaag PJFM, Luyendijk L, de Lange GG, van Eede PH, van Leeuwen AM, Frants R, Kruit

PJ, Baarsma GS, Kijlstra A, Feltkamp TEW : Genes on chromosome 14q and their role in the pathogenesis of HLA-B27 associated diseases. _Clin Exp Rheumatol_ 1987, 5 (suppl. 1): 89–95. Google

Scholar  * Derhaag PJFM, de Waal LP, Linssen A, Feltkamp TEW : Acute anterior uveitis and HLA-B27 subtypes. _Invest Ophthalmol Vis Sci_ 1988, 29: 1137–40. CAS  PubMed  Google Scholar  *

Benjamin R and Perham P : Guilt by association: HLA-B27 and ankylosing spondylitis. _Immunology today_ 1990, 11: 137–42. Article  CAS  Google Scholar  * Yu DTY, Choo SY, Schaack T :

Molecular mimicry in HLA-B27 related arthritis. _Ann Inern Med_ 1989, 111: 581–91. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Netherlands

Ophthalmic Research Institute and Central Laboratory for Bloodtransfusion Service, Amsterdam T E W Feltkamp Authors * T E W Feltkamp View author publications You can also search for this

author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Feltkamp, T. Ophthalmological significance of HLA associated uveitis.

_Eye_ 4, 839–844 (1990). https://doi.org/10.1038/eye.1990.133 Download citation * Issue Date: 01 November 1990 * DOI: https://doi.org/10.1038/eye.1990.133 SHARE THIS ARTICLE Anyone you share

the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer

Nature SharedIt content-sharing initiative