Cryptotanshinone but not tanshinone iia inhibits angiogenesis in vitro


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ABSTRACT In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of


angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of BAECs at ten micromolar ranges in vitro without cytotoxicity. Tanshinone IIA, another tanshinone isolated from S.


miltiorrhiza, which is structurally very similar to cryptotanshinone except C-15 position of dihydrofuran ring does not inhibit angiogenesis induced by bFGF. These results demonstrate that


cryptotanshinone is a new anti-angiogenic agent and double bond at C-15 position of the dihydrofuran ring plays a crucial role in the activity. SIMILAR CONTENT BEING VIEWED BY OTHERS


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17 December 2020 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Chemical Genomics National Research Laboratory, Department of Bioscience and Biotechnology, Institute of


Bioscience, Sejong University, 98 Kunja-dong, Kwangjin-gu, Seoul, Korea Jong Moon Hur Authors * Jong Moon Hur View author publications You can also search for this author inPubMed Google


Scholar * Joong Sup Shim View author publications You can also search for this author inPubMed Google Scholar * Hye Jin Jung View author publications You can also search for this author


inPubMed Google Scholar * Ho Jeong Kwon View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS This is an Open Access article distributed


under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and


reproduction in any medium, provided the original work is properly cited. Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hur, J., Shim, J., Jung, H. _et al._ Cryptotanshinone


but not tanshinone IIA inhibits angiogenesis _in vitro_. _Exp Mol Med_ 37, 133–137 (2005). https://doi.org/10.1038/emm.2005.18 Download citation * Published: 01 April 2005 * Issue Date: 01


April 2005 * DOI: https://doi.org/10.1038/emm.2005.18 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable


link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * abietane * angiogenesis * cryptotanshinone


* Salvia miltiorrhiza * tanshinone