Forskolin promotes astroglial differentiation of human central neurocytoma cells


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ABSTRACT Human central neurocytoma is a kind of the brain tumors that are usually found in anterior part of the lateral ventricles. In this study, we established conditions that allowed


proliferation of neurocytoma cells culture and analyzed characteristics of neurocytoma cells in vitro. For in vitro, a condition that used for culturing neural stem cells and contained basic


fibroblast growth factor (bFGF) provided high proliferation. RT-PCR analaysis showed that nestin was found in neurocytoma cells, indicating that the neurocytomas possess neural stem cell


properties. Interestingly, treatment of neurocytoma cells with forskolin increased expression of glial fibrillary acidic protein with a concomitant decrease in the nestin expression.


Forskolin also induced morphological changes of neurocytoma cells to adopt an astrocyte-like phenotype. The results suggest that neurocyotma cells may have properties of multipotent neural


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DIFFERENTIATION, CULTURING AND DEVELOPMENT Article Open access 13 January 2023 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Anatomy, School of Medicine, Ajou


University, Suwon, 442-749, Korea Bum Jun Kim Authors * Bum Jun Kim View author publications You can also search for this author inPubMed Google Scholar * Sung Soo Kim View author


publications You can also search for this author inPubMed Google Scholar * Young Im Kim View author publications You can also search for this author inPubMed Google Scholar * Sun Ha Paek


View author publications You can also search for this author inPubMed Google Scholar * Young Don Lee View author publications You can also search for this author inPubMed Google Scholar *


Haeyoung Suh-Kim View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS This is an Open Access article distributed under the terms of the


Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any


medium, provided the original work is properly cited. Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kim, B., Kim, S., Kim, Y. _et al._ Forskolin promotes astroglial


differentiation of human central neurocytoma cells. _Exp Mol Med_ 36, 52–56 (2004). https://doi.org/10.1038/emm.2004.7 Download citation * Published: 01 February 2004 * Issue Date: 01


February 2004 * DOI: https://doi.org/10.1038/emm.2004.7 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable


link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * astrocyte * central neurocytoma * forskolin


* neural stem cell, neuron * protein kinase A