Vitamin d replacement in pregnant women in rural north india: a pilot study

ABSTRACT Hypovitaminosis D is common in both urban and rural Indians. The dose of vitamin D needed for the treatment of its deficiency during pregnancy is not clear. We conducted a study in

rural Indians to evaluate the effect of cholecalciferol supplementation during routine antenatal visits on maternal 25 hydroxyvitamin D (25OHD) at delivery. Pregnant women received either no

cholecalciferol (Group A) or 60 000 U (Group B) in the fifth month of gestation or 120 000 U each in the fifth and seventh gestational months (Group C). Serum 25OHD was measured at baseline

(_n_=139) and at delivery (_n_=84). Median (interquartile range) 25OHD at baseline was low: 32.3 nmol/l (22.8–50.1 nmol/l). A significant increase in 25OHD at delivery was obtained only in

group C: 40.1 nmol/l (26.9–58.4 nmol/l) at baseline vs 53.4 nmol/l (41.2–88.0 nmol/l) after delivery, _P_<0.001. Only 20% of participants in Group C achieved 25OHD at delivery >80 

nmol/l, not significantly different from Group B. Cholecalciferol in doses of 120 000 U each in fifth and seventh gestational months was effective in raising 25OHD at delivery. Access

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SIMILAR CONTENT BEING VIEWED BY OTHERS PREVALENCE AND RISK FACTORS OF HYPOVITAMINOSIS D IN PREGNANT SPANISH WOMEN Article Open access 25 September 2020 VITAMIN D STATUS IN NON-PREGNANT WOMEN

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02 September 2020 REFERENCES * Balasubramanian K, Rajeswari J, Gulab, Govil YC, Agarwal AK, Kumar A _et al_. (2003). Varying role of vitamin D deficiency in the etiology of rickets in young

children vs. adolescents in northern India. _J Trop Pediatr_ 49, 201–206. Article  CAS  Google Scholar  * Balasubramanian S, Shivbalan S, Saravanakumar P (2006). Hypocalcemia due to vitamin

D deficiency in exclusively breast fed infants. _Ind Pediatr_ 43, 247–251. CAS  Google Scholar  * Brooke OG, Brown IR, Bone CDM, Carter ND, Cleeve NJ, Maxwell JD _et al_. (1980). Vitamin D

supplements in pregnant Asian women: effects on calcium status and fetal growth. _Br Med J_ 280, 751–754. Article  CAS  Google Scholar  * Datta S, Alfaham M, Davies DP, Dunstan F, Woodhead

S, Evans J _et al_. (2002). Vitamin D deficiency in pregnant women from a non-European ethnic minority population—an interventional study. _BJOG_ 109, 905–908. CAS  PubMed  Google Scholar  *

Holick MF, MacLaughlin JA, Doppelt SH (1981). Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an essential regulator. _Science_ 211, 590–593. Article  CAS 

Google Scholar  * Hollis BW, Wagner CL (2004). Assessment of dietary vitamin D requirements during pregnancy and lactation. _Am J Clin Nutr_ 79, 717–726. CAS  PubMed  Google Scholar  * Ilahi

M, Armas LAG, Heaney RP (2008). Pharmacokinetics of a single large dose of cholecalciferol. _Am J Clin Nutr_ 87, 688–691. Article  CAS  Google Scholar  * Madelenat P, Bastian H, Menn S

(2001). Winter supplementation in the 3rd trimester of pregnancy by a dose of 80,000 IU of vitamin D. _J Gynecol Obstet Biol Reprod (Paris)_ 30, 761–767. CAS  Google Scholar  * Marya RK,

Rathee S, Dua V, Sangwan K (1988). Effect of vitamin D supplementation during pregnancy on foetal growth. _Indian J Med Res_ 88, 488–492. CAS  PubMed  Google Scholar  * Saadi HF, Dawodu A,

Afandi BO, Zayed R, Benedict S, Nagelkerke N (2007). Efficacy of daily and monthly high-dose calciferol in vitamin D-deficient nulliparous and lactating women. _Am J Clin Nutr_ 85,

1565–1571. Article  CAS  Google Scholar  * Sachan A, Gupta R, Das V, Agarwal A, Awasthi PK, Bhatia V (2005). High prevalence of vitamin D deficiency among pregnant women and their newborns

in northern India. _Am J Clin Nutr_ 81, 1060–1064. Article  CAS  Google Scholar  * Sahu M, Bhatia V, Aggarwal A, Rawat V, Saxena P, Pandey A _et al_. (2009). Vitamin D deficiency in rural

girls and pregnant women despite abundant sunshine in northern India. _Clin Endocrinol_ 70, 680–684. Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS The authors

acknowledge the technical assistance of PK Awasthi and Intsar Ahmed and the assistance of Arjun Singh for studies in the community. Grant support (BT/PR 3552/SPD/11/349/2002) to V Bhatia.

BT/PR 3552/SPD/11/349/2002 to V Bhatia, from the Department of Biotechnology, Government of India. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Endocrinology, Sanjay Gandhi

Postgraduate Institute of Medical Sciences, Lucknow, India M Sahu & V Bhatia * Department of Obstetrics and Gynecology, Queen Mary's Hospital, King George's Medical University,

Lucknow, India V Das, A Aggarwal, V Rawat & P Saxena Authors * M Sahu View author publications You can also search for this author inPubMed Google Scholar * V Das View author

publications You can also search for this author inPubMed Google Scholar * A Aggarwal View author publications You can also search for this author inPubMed Google Scholar * V Rawat View

author publications You can also search for this author inPubMed Google Scholar * P Saxena View author publications You can also search for this author inPubMed Google Scholar * V Bhatia

View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to V Bhatia. ADDITIONAL INFORMATION _Contributors:_ VB:

conceptualization, design of the study, analysis of data, writing of the paper; MS: design of the study, collection of data, analysis of data, writing of the paper; AA: design of the study,

analysis of data; VR: collection of data; PS: collection of data; VD: design of the study. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Sahu, M., Das,

V., Aggarwal, A. _et al._ Vitamin D replacement in pregnant women in rural north India: a pilot study. _Eur J Clin Nutr_ 63, 1157–1159 (2009). https://doi.org/10.1038/ejcn.2009.27 Download

citation * Received: 05 October 2008 * Revised: 21 December 2008 * Accepted: 03 March 2009 * Published: 20 May 2009 * Issue Date: September 2009 * DOI: https://doi.org/10.1038/ejcn.2009.27

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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * cholecalciferol * 25-hydroxyvitamin D * pregnancy * Indians