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Dyslipidemia increase the risk for coronary heart disease in part by impairing endothelial integrity. Endothelial progenitor cells(EPCs) play a pivotal role in reendotheliazation. In
previous study, oxidized low-density lipoprotein (oxLDL) affects the apoptosis of the EPCs. However, the precise mechanism is still unclear. Therefore, we focused in this study to understand
whether oxLDL can induce caspase-3 activity and insulin like growth factor-1(IGF-1) can prevent the EPC by the decrease the caspase-3 activity and the apoptosis in the EPCs. EPCs were
isolated from peripheral blood and characterized. The EPCs were cultured with IGF-1 for 30 min and then were treated with oxLDL for 48 h. The apoptosis of the Endothelial progenitor cells
was checked by the flow cytometry and, while caspase-3 activity was measured simultaneously. After the EPC were treated, the mean of apoptotic rates and caspase-3 enzyme activity
significantly decreased. in EPCs treated with IGF-1, the decrease of the caspase-3 activity by oxLDL was blocked and apoptosis prevented. Therefore, IGF-1 can reduced the apoptosis of
endothelial progenitor cells induced by oxLDL. This effect may be mediated by significantly suppressing caspase-3 activity.
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