Generating cd8αα iels from two sources of thymic precursors

Access through your institution Buy or subscribe As the interface between the gut lumen and the body, the intestinal epithelial layer is continuously exposed to large numbers of microbial

and dietary antigens. Consequently, intestinal homeostasis requires sophisticated immune networks that effectively clear pathogenic microbes while maintaining tolerance to harmless antigens.

To achieve this balance, intraepithelial lymphocytes (IELs) that are scattered among intestinal epithelial cells carry out numerous important functions.1 Most IELs are a heterogeneous

population of T lymphocytes, including both TCRαβ+ and TCRγδ+ IELs. Unlike T cells in other tissues, most TCRαβ+ IELs in the small intestine belong to the CD8+ subset.2 Moreover, a sizeable

fraction of these TCRαβ+IELs are CD4−CD8α+CD8β− cells,3 which are referred to as CD8αα IELs based on their expression of the CD8αα homodimer. This is a preview of subscription content,

access via your institution RELEVANT ARTICLES Open Access articles citing this article. * SINGLE-CELL ANALYSIS REVEALS THE ORIGINS AND INTRAHEPATIC DEVELOPMENT OF LIVER-RESIDENT

IFN-Γ-PRODUCING ΓΔ T CELLS * Yuan Hu * , Keke Fang *  … Cai Zhang _Cellular & Molecular Immunology_ Open Access 10 March 2021 ACCESS OPTIONS Access through your institution Subscribe to

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regulates thymocyte and T-cell migration. _Nature_ 2006; 442: 299–302. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Institute of Immunology

and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, 230027, Hefei, Anhui, China Lu

Bai & Hui Peng Authors * Lu Bai View author publications You can also search for this author inPubMed Google Scholar * Hui Peng View author publications You can also search for this

author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Hui Peng. ETHICS DECLARATIONS CONFLICT OF INTEREST The authors declare no conflict of interest. RIGHTS AND PERMISSIONS

Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bai, L., Peng, H. Generating CD8αα IELs from two sources of thymic precursors. _Cell Mol Immunol_ 15, 640–641 (2018).

https://doi.org/10.1038/cmi.2017.93 Download citation * Received: 25 July 2017 * Accepted: 01 August 2017 * Published: 11 September 2017 * Issue Date: June 2018 * DOI:

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