Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis

ABSTRACT Recent studies have identified olfactory ecto-mesenchymal stem cells (OE-MSCs) as a new type of resident stem cell in the olfactory lamina propria. However, it remains unclear

whether OE-MSCs possess any immunoregulatory functions. In this study, we found that mouse OE-MSCs expressed higher transforming growth factor-beta and interleukin-10 levels than bone

marrow-derived MSCs. In culture, OE-MSCs exerted their immunosuppressive capacity via directly suppressing effector T-cell proliferation and increasing regulatory T (Treg) cell expansion. In

mice with collagen-induced arthritis, adoptive transfer of OE-MSCs markedly suppressed arthritis onset and disease severity, which was accompanied by increased Treg cells and reduced

Th1/Th17 cell responses _in vivo_. Taken together, our findings identified a novel function of OE-MSCs in regulating T-cell responses, indicating that OE-MSCs may represent a new cell

therapy for the treatment of rheumatoid arthritis and other autoimmune diseases. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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Biol_ 2013; 1059: 107–114 Article  Google Scholar  Download references ACKNOWLEDGEMENTS This work was supported by grants from the National Natural Science Foundation of China (Grant Nos.

31470881, 81072453), the Specialized Research Fund for the Doctoral Program of Higher Education (Grant No. 20133227110008), the Health Department Foundation of Jiangsu Province (Grant No.

Z201312), the Graduate Student Research and the Innovation Program of Jiangsu Province (Grant No. KYLX_1074), the Jiangsu Province ‘333’ Project (Grant No. BRA2015197), the Priority Academic

Program Development of Jiangsu Higher Education Institutions, the National Basic Research Program of China (2014CB541904), and the Hong Kong Croucher Foundation. AUTHOR INFORMATION Author

notes * S Wang, Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang 212002, China. E-mail: [email protected] * L Lu, Department of

Pathology and Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China. E-mail:[email protected] AUTHORS AND AFFILIATIONS * Department of Laboratory Medicine, The

Affiliated People’s Hospital, Jiangsu University, Zhenjiang, China Ke Rui, Xinyi Tang & Shengjun Wang * Institute of Laboratory Medicine and Department of Histology, Jiangsu Key

Laboratory of Laboratory Medicine, Jiangsu University, Zhenjiang, China Ke Rui, Zhijiang Zhang, Jie Tian, Jie Ma, Huaxi Xu & Shengjun Wang * Department of Pathology and Center for

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INTERESTS The authors declare that no conflicts of interest exist. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Rui, K., Zhang, Z., Tian, J. _et al._

Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis. _Cell Mol Immunol_ 13, 401–408 (2016). https://doi.org/10.1038/cmi.2015.82 Download

citation * Received: 18 May 2015 * Revised: 03 August 2015 * Accepted: 03 August 2015 * Published: 21 September 2015 * Issue Date: May 2016 * DOI: https://doi.org/10.1038/cmi.2015.82 SHARE

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