Direct effects of activin a on the activation of mouse macrophage raw264. 7 cells

ABSTRACT Macrophages play critical roles in innate immune and acquired immune _via_ secreting pro-inflammatory mediators, phagocytosing microorganisms and presenting antigens. Activin A, a

member of transforming growth factor β (TGF-β) superfamily, is produced by macrophages and microglia cells. In this study, we reported a direct effect of activin A as a pro-inflammatory

factor on mouse macrophage cell line RAW264.7 cells. Our data revealed that activin A could not only increase IL-1β and IL-6 production from RAW264.7 cells, but also promote pinocytic and

phagocytic activities of RAW264.7 cells. In addition, activin A obviously up-regulated MHC II expression on the surface of RAW264.7 cells, whereas did not influence MHC I expression. Activin

A also enhanced CD80 expression, which is a marker of activated macrophages, but did not influence RAW264.7 cell proliferation. These data suggest that activin A may regulate primary

macrophage-mediated innate and acquired immune response _via_ promoting the activation of rest macrophages. Access through your institution Buy or subscribe This is a preview of subscription

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07 July 2023 AUTHOR INFORMATION Author notes * Jingyan Ge and Yinan Wang: These authors contributed equally to this work AUTHORS AND AFFILIATIONS * Department of Immunology, Norman Bethune

College of Medicine, Jilin University, Changchun, 130021, China Jingyan Ge, Yinan Wang, Ye Feng, Haiyan Liu, Xueling Cui, Fangfang Chen, Guixiang Tai & Zhonghui Liu * Department of

Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130031, China Ye Feng Authors * Jingyan Ge View author publications You can also search for this author inPubMed Google

Scholar * Yinan Wang View author publications You can also search for this author inPubMed Google Scholar * Ye Feng View author publications You can also search for this author inPubMed 

Google Scholar * Haiyan Liu View author publications You can also search for this author inPubMed Google Scholar * Xueling Cui View author publications You can also search for this author

inPubMed Google Scholar * Fangfang Chen View author publications You can also search for this author inPubMed Google Scholar * Guixiang Tai View author publications You can also search for

this author inPubMed Google Scholar * Zhonghui Liu View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Zhonghui Liu.

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ge, J., Wang, Y., Feng, Y. _et al._ Direct Effects of Activin A on the Activation of Mouse Macrophage

RAW264.7 Cells. _Cell Mol Immunol_ 6, 129–133 (2009). https://doi.org/10.1038/cmi.2009.18 Download citation * Received: 13 February 2009 * Accepted: 01 April 2009 * Issue Date: 01 April 2009

* DOI: https://doi.org/10.1038/cmi.2009.18 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not

currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * activin * macrophage * MHC II * CD80