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Macrophages play critical roles in innate immune and acquired immune via secreting pro-inflammatory mediators, phagocytosing microorganisms and presenting antigens. Activin A, a member of
transforming growth factor β (TGF-β) superfamily, is produced by macrophages and microglia cells. In this study, we reported a direct effect of activin A as a pro-inflammatory factor on
mouse macrophage cell line RAW264.7 cells. Our data revealed that activin A could not only increase IL-1β and IL-6 production from RAW264.7 cells, but also promote pinocytic and phagocytic
activities of RAW264.7 cells. In addition, activin A obviously up-regulated MHC II expression on the surface of RAW264.7 cells, whereas did not influence MHC I expression. Activin A also
enhanced CD80 expression, which is a marker of activated macrophages, but did not influence RAW264.7 cell proliferation. These data suggest that activin A may regulate primary
macrophage-mediated innate and acquired immune response via promoting the activation of rest macrophages.
Jingyan Ge and Yinan Wang: These authors contributed equally to this work
Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun, 130021, China
Jingyan Ge, Yinan Wang, Ye Feng, Haiyan Liu, Xueling Cui, Fangfang Chen, Guixiang Tai & Zhonghui Liu
Department of Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130031, China
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