Splenectomy prior to allogeneic hematopoietic sct increases the risk of post-transplant lymphoproliferative disease

Access through your institution Buy or subscribe Splenectomy before allo-SCT is usually performed in some individuals diagnosed with lymphoma and myelofibrosis.1, 2 However, much is still

unknown regarding the impact of splenectomy on the outcome of allo-SCT. Previous work has suggested an association between acute and chronic GVHD and splenectomy prior to allo-SCT.3, 4

Conversely, more recent work failed to see this correlation and instead showed an association between splenectomy and relapse after CML.5, 6 In a recent ‘Center for International Blood and

Marrow Transplant Research’ (CIBMTR) report, the authors analyzed the effects of spleen status on engraftment and other early outcomes after allo-SCT.7 In this material, over 9000 patients

were transplanted with myeloablative conditioning (MAC) and the authors showed a decrease in time of neutrophil and platelet engraftment in patients with splenectomy compared to individuals

with normal spleen status. However, when analyzing other complications or the OS of the patient cohort no difference was observed between individuals with and those without a spleen. This is

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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Thieblemont C, Davi F, Noguera ME,

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Scholar  * Uhlin M, Wikell H, Sundin M, Blennow O, Maeurer M, Ringden O _et al_. Risk factors for Epstein Barr virus related post-transplant lymphoproliferative disease after allogeneic

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AUTHORS AND AFFILIATIONS * Department of Laboratory Medicine, Therapeutic Immunology Unit, Karolinska Institutet, Huddinge, Sweden M Uhlin, M M Norström, J Mattsson & M Remberger *

Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Huddinge, Sweden M Uhlin, M M Norström, J Mattsson & M Remberger * Clinical Immunology and Transfusion

Medicine, Karolinska University Hospital, Huddinge, Sweden M Uhlin Authors * M Uhlin View author publications You can also search for this author inPubMed Google Scholar * M M Norström View

author publications You can also search for this author inPubMed Google Scholar * J Mattsson View author publications You can also search for this author inPubMed Google Scholar * M

Remberger View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to M Uhlin. ETHICS DECLARATIONS COMPETING INTERESTS The

authors declare no conflict of interest. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Uhlin, M., Norström, M., Mattsson, J. _et al._ Splenectomy prior

to allogeneic hematopoietic SCT increases the risk of post-transplant lymphoproliferative disease. _Bone Marrow Transplant_ 49, 463–464 (2014). https://doi.org/10.1038/bmt.2013.201 Download

citation * Published: 16 December 2013 * Issue Date: March 2014 * DOI: https://doi.org/10.1038/bmt.2013.201 SHARE THIS ARTICLE Anyone you share the following link with will be able to read

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