Association between syndecan-1 expression and clinical outcome in squamous cell carcinoma of the head and neck

ABSTRACT Syndecans are a family of cell-surface heparan sulphate proteoglycans which are involved in cell-matrix interactions and growth factor binding. Syndecan-1 binds basic fibroblast

growth factor (bFGF) and several components of the extracellular matrix. Syndecan-1 expression is induced during keratinocyte differentiation and reduced during the formation of squamous

cell carcinomas (SCCs). The purpose of this study was to examine the association of syndecan-1 expression with prognostic factors and clinical outcome in SCC of the head and neck. Frozen

sections of 29 primary SCCs were analysed for syndecan-1 expression using immunohistochemical methods. Intermediate or strong staining for syndecan-1 was associated with a smaller primary

tumour size (P = 0.0005) and higher histological grade of differentiation (P = 0.006) than negative or weakly positive staining. In a univariate analysis, syndecan-1-positive tumours were

associated with higher overall (P = 0.001) and recurrence-free survival (P = 0.003) than those tumours with no or little syndecan-1 expression. The results suggest that syndecan-1 could be

an important prognostic factor of SCC of the head and neck. Further studies on the prognostic significance of syndecan-1 expression in SCCs are warranted. Access through your institution Buy

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MYXOFIBROSARCOMAS AND UNDIFFERENTIATED PLEOMORPHIC SARCOMAS Article Open access 29 July 2021 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Turku Centre for Biotechnology, Finland P Inki

Authors * P Inki View author publications You can also search for this author inPubMed Google Scholar * H Joensuu View author publications You can also search for this author inPubMed Google

Scholar * R Grénman View author publications You can also search for this author inPubMed Google Scholar * P Klemi View author publications You can also search for this author inPubMed 

Google Scholar * M Jalkanen View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Inki, P., Joensuu, H., Grénman, R. _et al._ Association between syndecan-1 expression and clinical outcome in squamous cell carcinoma of the head and neck. _Br J Cancer_ 70, 319–323

(1994). https://doi.org/10.1038/bjc.1994.300 Download citation * Issue Date: 01 August 1994 * DOI: https://doi.org/10.1038/bjc.1994.300 SHARE THIS ARTICLE Anyone you share the following link

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