The effects of vasopressin infusion on hepatic haemodynamics in an experimental model of liver metastases


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ABSTRACT Vasoactive drugs have a variety of effects upon splanchnic and hepatic haemodynamics which may alter tumour blood flow and potentiate the delivery of a chemotherapeutic drug to


hepatic tumour. We have investigated the effects of vasopressin infusion on hepatic tumour blood flow in an experimental model of liver tumour. Hepatic tumour was induced by the intraportal


inoculation of HSN sarcoma cells. Hepatic and splanchnic blood flow was determined using a dual reference microsphere technique before and after an intravenous infusion of vasopressin at a


dose of 0.1 mU kg-1 min-1 for 10 min. There was a significant increase in systemic arterial blood pressure associated with a rise in portal venous inflow (P less than 0.01, Wilcoxen Signed


rank Test) and a significant fall in hepatic arterial flow (P less than 0.05). The tumour: liver blood flow ratio was significantly increased by vasopressin infusion (P less than 0.02).


Vasopressin infusion decreases hepatic arterial flow and increases tumour blood flow which may potentiate the delivery of a regionally delivered chemotherapeutic drug to hepatic tumour.


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ENHANCES THE GROWTH OF CC531 RAT COLORECTAL CANCER CELLS BOTH IN VITRO AND IN VIVO Article Open access 08 March 2021 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * University Department of


Surgery, Glasgow Royal Infirmary, UK DM Hemingway Authors * DM Hemingway View author publications You can also search for this author inPubMed Google Scholar * D Chang View author


publications You can also search for this author inPubMed Google Scholar * TG Cooke View author publications You can also search for this author inPubMed Google Scholar * SA Jenkins View


author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hemingway, D., Chang, D.,


Cooke, T. _et al._ The effects of vasopressin infusion on hepatic haemodynamics in an experimental model of liver metastases. _Br J Cancer_ 64, 212–214 (1991).


https://doi.org/10.1038/bjc.1991.278 Download citation * Issue Date: 01 August 1991 * DOI: https://doi.org/10.1038/bjc.1991.278 SHARE THIS ARTICLE Anyone you share the following link with


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