Tumour necrosis factor production and natural killer cell activity in peripheral blood during treatment with recombinant tumour necrosis factor

ABSTRACT Tumour necrosis factor (TNF) has been found to be an important immunomodulator. Among other functions TNF activates natural killer (NK) cells and stimulates monocytes/macrophages in

an autocrine fashion. TNF production and NK activity in peripheral blood mononuclear cells were determined in a clinical phase I study in which recombinant human (rh) TNF was administered

as a continuous infusion weekly for a period of 8 weeks. Even though TNF production and NK activity were significantly reduced directly after rhTNF infusion the effect proved to be transient

and most pronounced at the first rhTNF administration. One day after completion of the rhTNF infusion the peripheral cells released more TNF into the supernatant compared to TNF activity

immediately before the rhTNF infusion. This effect was conspicuous in non-stimulated cultures. After repeated rhTNF infusions both stimulated and non-stimulated TNF production of the

peripheral blood mononuclear cells was increased. NK cell activity was also enhanced after repeated cycles of rhTNF administration as compared to early rhTNF treatment. Thus, repeated rhTNF

infusions lead to a stimulatory effect on TNF production and NK activity of peripheral blood cells. Access through your institution Buy or subscribe This is a preview of subscription

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MICROENVIRONMENT? Article 21 June 2021 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Institute of Immunology and Genetics, German Cancer Research Centre, Heidelberg, FRG DN Männel Authors *

DN Männel View author publications You can also search for this author inPubMed Google Scholar * A Kist View author publications You can also search for this author inPubMed Google Scholar *

AD Ho View author publications You can also search for this author inPubMed Google Scholar * U Räth View author publications You can also search for this author inPubMed Google Scholar * P

Reichardt View author publications You can also search for this author inPubMed Google Scholar * B Wiedenmann View author publications You can also search for this author inPubMed Google

Scholar * E Schlick View author publications You can also search for this author inPubMed Google Scholar * H Kirchner View author publications You can also search for this author inPubMed 

Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Männel, D., Kist, A., Ho, A. _et al._ Tumour necrosis factor production and natural killer

cell activity in peripheral blood during treatment with recombinant tumour necrosis factor. _Br J Cancer_ 60, 585–588 (1989). https://doi.org/10.1038/bjc.1989.318 Download citation * Issue

Date: 01 October 1989 * DOI: https://doi.org/10.1038/bjc.1989.318 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

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