Correlation between size and external temperature of the isis 130 tumour after treatment with cytostatic agents

ABSTRACT The reduction in size of the experimental ISIS 130 tumour has been investigated in LOU rats under the influence of increasing doses of cytostatic agents belonging to different

classes. External temperatures of tumours as well as rectal temperatures have been measured at the same time, twice daily, during the whole experiment. The greater the decrease in the tumour

size after drug administration, the larger was the decrease in external temperature of tumour. The rectal temperatures remained fairly stable, thus differences between the tumour and rectal

temperatures increased. A possible correlation between the reduction of tumour size and the decrease of external temperature of tumour has been traced for every cytostatic agent, and the

same linear relationship has been found to link these two parameters. The decrease in external temperature of tumour may, moreover, predict the decrease in tumour size within a term of 1-2

days. Measurement of the magnitude of the transient tumour hypothermia of ISIS 130, following chemotherapy, would represent a new method for measuring the efficiency and duration of action

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Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS TEMPERATURE ELEVATION IN TISSUE DETECTED _IN VIVO_ BASED ON STATISTICAL ANALYSIS OF ULTRASONIC SCATTERED ECHOES Article Open

access 03 June 2020 TUMOR THERAPEUTIC RESPONSE MONITORED BY TELEMETRIC TEMPERATURE SENSING, A PRECLINICAL STUDY ON IMMUNOTHERAPY AND CHEMOTHERAPY Article Open access 12 May 2023 CONTINUOUS

AND NON-INVASIVE THERMOGRAPHY OF MOUSE SKIN ACCURATELY DESCRIBES CORE BODY TEMPERATURE PATTERNS, BUT NOT ABSOLUTE CORE TEMPERATURE Article Open access 26 November 2020 Authors * Ph Nickers

View author publications You can also search for this author inPubMed Google Scholar * L Oosters View author publications You can also search for this author inPubMed Google Scholar * F

Brasseur View author publications You can also search for this author inPubMed Google Scholar * L Deckers-Passau View author publications You can also search for this author inPubMed Google

Scholar * H Maisin View author publications You can also search for this author inPubMed Google Scholar * C Deckers View author publications You can also search for this author inPubMed 

Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Nickers, P., Oosters, L., Brasseur, F. _et al._ Correlation between size and external

temperature of the ISIS 130 tumour after treatment with cytostatic agents. _Br J Cancer_ 54, 61–66 (1986). https://doi.org/10.1038/bjc.1986.152 Download citation * Issue Date: 01 July 1986 *

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