Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours

ABSTRACT The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice. Polyamine

levels and the numbers of tumour-cell colonies in the lungs were determined at weekly intervals. Putrescine levels in both erythrocytes and plasma significantly increased 1 week after tumour

inoculation. Three weeks after inoculation, however, putrescine levels in the erythrocytes showed a greater increase than those in plasma. Spermidine and spermine levels were initially high

at 2 weeks in plasma and at 4 weeks in erythrocytes. However, by 6 weeks the spermidine levels showed a greater increase in erythrocytes than in plasma. These data suggest that erythrocytes

may absorb and store polyamines released into the circulation. This finding was subsequently applied to human studies. Fifty-two untreated patients with solid tumours were examined in the

preoperative period. All erythrocyte polyamine levels from patients were significantly higher than those from control subjects. Plasma spermidine levels in patients were significantly higher

than those in controls, whereas plasma putrescine and spermine levels showed no significant increase. The frequency of raised levels of putrescine, spermidine and spermine in erythrocytes

was significantly greater than in plasma. These results suggest that polyamine levels in erythrocytes may provide useful information for the detection of cancer. Access through your

institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 24 print

issues and online access $259.00 per year only $10.79 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to

local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT

BEING VIEWED BY OTHERS POLYAMINES IN CANCER: INTEGRATING ORGANISMAL METABOLISM AND ANTITUMOUR IMMUNITY Article 27 April 2022 CIRCADIAN AND CHEMOTHERAPY-RELATED CHANGES IN URINARY MODIFIED

NUCLEOSIDES EXCRETION IN PATIENTS WITH METASTATIC COLORECTAL CANCER Article Open access 14 December 2021 PLASMA PROTEOME OF GROWING TUMORS Article Open access 27 July 2023 Authors * H Takami

View author publications You can also search for this author inPubMed Google Scholar * K Nishioka View author publications You can also search for this author inPubMed Google Scholar RIGHTS

AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Takami, H., Nishioka, K. Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid

tumours. _Br J Cancer_ 41, 751–756 (1980). https://doi.org/10.1038/bjc.1980.137 Download citation * Issue Date: 01 May 1980 * DOI: https://doi.org/10.1038/bjc.1980.137 SHARE THIS ARTICLE

Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided

by the Springer Nature SharedIt content-sharing initiative