Ultrastructure of cell surface abnormalities in neoplastic histiocytes


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ABSTRACT In an ultrastructural study by transmission and scanning electron microscopy of two cases of malignant histiocytosis and a case of leukaemic reticulum-cell sarcoma, unusual


blisters, blebs and worm-like processes were detected on the cell surfaces. The blisters (containing clear fluid) appear to develop by a single-membrane-bound vacuole approaching the cell


membrane, and acquiring another membrane on discharging from the cell. The blebs (containing cytoplasm) appear to correspond to the already described phenomenon of zeiosis. The term


"vermipodia" is given to the worm-like processes. The underlying factors responsible for these phenomena is not clear, but the exocytosis of the clear blisters resembled that of


leukaemic blasts exposed to the action of vinca alkaloids. As two of the cases were being treated with vincristine, it may be that a drug action is implicated. However, it is also possible


that these changes may be the morphological expression of some of the changes in the cell surface membrane that occur in malignant transformation. Access through your institution Buy or


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IN SITU STRUCTURE AND ORGANIZATION OF THE INFLUENZA C VIRUS SURFACE GLYCOPROTEIN Article Open access 16 March 2021 IN SITU STRUCTURE OF VIRUS CAPSIDS WITHIN CELL NUCLEI BY CORRELATIVE LIGHT


AND CRYO-ELECTRON TOMOGRAPHY Article Open access 19 October 2020 HISTIOCYTIC DISORDERS Article 07 October 2021 Authors * L F Skinnider View author publications You can also search for this


author inPubMed Google Scholar * F N Ghadially View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS


ARTICLE CITE THIS ARTICLE Skinnider, L., Ghadially, F. Ultrastructure of cell surface abnormalities in neoplastic histiocytes. _Br J Cancer_ 35, 657–667 (1977).


https://doi.org/10.1038/bjc.1977.101 Download citation * Issue Date: 01 May 1977 * DOI: https://doi.org/10.1038/bjc.1977.101 SHARE THIS ARTICLE Anyone you share the following link with will


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