Tissue nad levels and the response to irradiation or cytotoxic drugs


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ABSTRACT It has been shown that when 32P counting from a tumour is continuous peaks in the count rate can sometimes be induced by large doses of nicotinic acid, nicotinic acid, nicotinamide


or 3-acetylpyridine, but not by 6-aminonicotinamide. These 32P counting peaks have been associated with the time of maximal new synthesis of nicotinamide adenine dinucleotide (NAD).


Sensitization to irradiation or some cytotoxic drugs has been found at the peak of this new NAD synthesis. The radioprotective agents cysteamine, 2-aminoethylisothiouronium bromide (AET) and


serotonin have been found to cause a rapid fall in tissue NAD levels. The results have been briefly discussed. Access through your institution Buy or subscribe This is a preview of


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APPLIED SEVERAL DAYS AFTER EXPOSURE REDUCES LETHALITY OF SEVERELY IRRADIATED MICE Article Open access 12 April 2021 ESTIMATION OF RADIATION DOSE FROM INGESTED TRITIUM IN HUMANS BY


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access 13 November 2023 Authors * G Calcutt View author publications You can also search for this author inPubMed Google Scholar * S M Ting View author publications You can also search for


this author inPubMed Google Scholar * A W Preece View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT


THIS ARTICLE CITE THIS ARTICLE Calcutt, G., Ting, S. & Preece, A. Tissue NAD Levels and the Response to Irradiation or Cytotoxic Drugs. _Br J Cancer_ 24, 380–388 (1970).


https://doi.org/10.1038/bjc.1970.44 Download citation * Issue Date: 01 March 1970 * DOI: https://doi.org/10.1038/bjc.1970.44 SHARE THIS ARTICLE Anyone you share the following link with will


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