Synergism of hydrochlorothiazide and nitrendipine on reduction of blood pressure and blood pressure variability in spontaneously hypertensive rats

ABSTRACT AIM: To investigate the possible synergism of hydrochlorothiazide and nitrendipine on reducing both blood pressure (BP) and blood pressure variability (BPV) in spontaneously

hypertensive rats (SHR). METHODS: Seventy animals were randomly divided into seven groups. The doses were 5 and 10 mg/kg for nitrendipine, 10 and 20 mg/kg for hydrochlorothiazide and 10+5,

20+10 mg/kg, respectively, for the combination of these two drugs and 0.8% carboxymethylcellulose as control. The drugs were given via a catheter of gastric fistula. BP was then continuously

recorded for 5 h from 1 h before drug administration to the end of 4th hour after drug administration, in conscious and freely moving rats. RESULTS: The effects on both BP and BPV reduction

of the combination of hydrochlorothiazide and nitrendipine were greater than the single drug in SHR. The two drugs possessed an obvious synergism on both systolic blood pressure (_q_=1.79

with small dose and _q_=1.23 with large dose) and systolic blood pressure variability reduction (_q_=1.79 with small dose and _q_=1.39 with large dose) in SHR. CONCLUSION: The present work

clearly demonstrated that there was a synergistic effect between hydrochlorothiazide and nitrendipine in lowering and stabilizing BP in SHR. SIMILAR CONTENT BEING VIEWED BY OTHERS

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Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China Ping Han, Zheng-xu Chu, Fu-ming Shen, He-hui Xie & Ding-feng Su Authors * Ping Han View

author publications You can also search for this author inPubMed Google Scholar * Zheng-xu Chu View author publications You can also search for this author inPubMed Google Scholar * Fu-ming

Shen View author publications You can also search for this author inPubMed Google Scholar * He-hui Xie View author publications You can also search for this author inPubMed Google Scholar *

Ding-feng Su View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Ding-feng Su. ADDITIONAL INFORMATION Project

supported by grants from the High Technology Research and Development (863) Program of China (2002 AA2Z346C) and the Shanghai Foundation for Science and Technology Development (No 03JC14001,

04JC14001). RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Han, P., Chu, Zx., Shen, Fm. _et al._ Synergism of hydrochlorothiazide and nitrendipine on

reduction of blood pressure and blood pressure variability in spontaneously hypertensive rats. _Acta Pharmacol Sin_ 27, 1575–1579 (2006). https://doi.org/10.1111/j.1745-7254.2006.00366.x

Download citation * Received: 21 February 2006 * Accepted: 11 April 2006 * Issue Date: 01 December 2006 * DOI: https://doi.org/10.1111/j.1745-7254.2006.00366.x SHARE THIS ARTICLE Anyone you

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Springer Nature SharedIt content-sharing initiative KEYWORDS * blood pressure * blood pressure variability * hydrochlorothiazide * hypertension * nitrendipine * spontaneously hypertensive

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