Iodide sensitizes genetically modified non-small cell lung cancer cells to ionizing radiation

ABSTRACT While external ionizing radiation has been used for treating non-small cell lung cancer (NSCLC), improved efficacy of this modality would be an important advance. Ectopic expression

of the sodium iodide symporter (NIS) and thyroperoxidase (TPO) genes in NSCLC cells facilitated concentration of iodide in NSCLC cells, which markedly induced apoptosis _in vitro_ and _in

vivo_. Pre-incubation of the NIS/TPO-modified NSCLC cells in iodide followed by ionizing radiation generates bystander tumoricidal effects and potently enhances tumor cell killing. This

iodide-induced bystander effect is associated with enhanced gap junction intercellular communication (GJIC) activity and increased connexin-43 (Cx43) expression. Thus, iodide may serve as an

enhancer to markedly improve the efficacy of radiation therapy in combined therapeutic modalities. Access through your institution Buy or subscribe This is a preview of subscription

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INDUCES TRIP13 EXPRESSION, CONFERRING RADIORESISTANCE IN LUNG CANCER CELLS Article Open access 06 January 2025 IMAGING NRF2 ACTIVATION IN NON-SMALL CELL LUNG CANCER WITH POSITRON EMISSION

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Download references ACKNOWLEDGEMENTS This work is supported by The UCLA SPORE in Lung Cancer, National Institutes of Health P50 CA90388, R01 CA085686 (SMD), Medical Research Funds from the

Department of Veteran Affairs, and the Tobacco-Related Disease Research Program of the University of California. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Pulmonary and

Critical Care Medicine, David Geffen School of Medicine at UCLA and Veterans Affairs Greater Los Angeles Healthcare System, CA, USA L Zhang, S Sharma, S M Dubinett & M Huang * Division

of Endocrinology and Metabolism, Department of Medicine, David Geffen School of Medicine at UCLA and Veterans Affairs Greater Los Angeles Healthcare System, CA, USA J M Hershman & G A

Brent * Lung Cancer Research Program of the Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA and Veterans Affairs Greater Los Angeles Healthcare System, CA, USA S

M Dubinett * Department of Pathology, David Geffen School of Medicine at UCLA and Veterans Affairs Greater Los Angeles Healthcare System, CA, USA S M Dubinett & M Huang Authors * L

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M Hershman View author publications You can also search for this author inPubMed Google Scholar * G A Brent View author publications You can also search for this author inPubMed Google

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Google Scholar CORRESPONDING AUTHOR Correspondence to M Huang. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Zhang, L., Sharma, S., Hershman, J. _et

al._ Iodide sensitizes genetically modified non-small cell lung cancer cells to ionizing radiation. _Cancer Gene Ther_ 13, 74–81 (2006). https://doi.org/10.1038/sj.cgt.7700875 Download

citation * Received: 15 November 2004 * Revised: 23 April 2005 * Accepted: 23 June 2005 * Published: 29 July 2005 * Issue Date: 01 January 2006 * DOI: https://doi.org/10.1038/sj.cgt.7700875

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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * lung cancer * iodide * radiation * gene therapy