Regional hemodynamic effects of dopamine in the indomethacin-treated preterm infant

ABSTRACT OBJECTIVE: We have previously demonstrated that dopamine induces selective renal vasodilation without affecting cerebral and mesenteric blood flow in ≤32 weeks' gestation

normotensive preterm infants during the first postnatal day. In the present study, we have examined whether pretreatment with indomethacin affects the regional hemodynamic response to

dopamine in >1-day-old normotensive preterm infants with similar gestational age. STUDY DESIGN: The pulsatility index (PI) was used to assess the dopamine-induced changes in renal,

mesenteric, and cerebral blood flow using color Doppler ultrasonography in 20 indomethacin-treated normotensive preterm neonates with patent ductus arteriosus (gestational age: 27.2±1.5

weeks; postnatal age: 35.7±8.2 hours). Dopamine (5 μg/kg per minute) was started 4.9±2.1 hours (range: 2 to 8 hours) after the first dose of indomethacin to combat oliguria and/or impaired

peripheral perfusion. Blood flow velocity measurements were obtained immediately before and 10 minutes after the start of dopamine with each subject serving as his/her own control. RESULTS:

Dopamine increased heart rate and urine output but did not affect blood pressure at the dose applied. Dopamine decreased the PI in the renal and superior mesenteric artery (2.6±1.32 vs.

1.61±0.7 and 2.36±1.12 vs. 1.76±0.64, respectively; _p_<0.05) whereas the PI in the middle cerebral artery remained unchanged. These results are consistent with a dopamine-induced

increase in renal and mesenteric blood flow without an effect on cerebral blood flow. CONCLUSIONS: When started at least 2 hours after the first dose of indomethacin, dopamine induces renal

and mesenteric vasodilation without affecting cerebral hemodynamics in the >1-day-old indomethacin-treated preterm infant. Access through your institution Buy or subscribe This is a

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Jacquelyn R. Evans for her valuable help during the preparation of the manuscript. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, Division of Neonatology, The

Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA Istvan Seri MD, PhD * Department of Pediatrics, Section of Newborn Pediatrics, Pennsylvania

Hospital, Philadelphia, PA, USA Soraya Abbasi MD, Dennis C Wood & Jeffrey S Gerdes MD Authors * Istvan Seri MD, PhD View author publications You can also search for this author inPubMed 

Google Scholar * Soraya Abbasi MD View author publications You can also search for this author inPubMed Google Scholar * Dennis C Wood View author publications You can also search for this

author inPubMed Google Scholar * Jeffrey S Gerdes MD View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions

ABOUT THIS ARTICLE CITE THIS ARTICLE Seri, I., Abbasi, S., Wood, D. _et al._ Regional Hemodynamic Effects of Dopamine in the Indomethacin-Treated Preterm Infant. _J Perinatol_ 22, 300–305

(2002). https://doi.org/10.1038/sj.jp.7210698 Download citation * Published: 28 May 2002 * Issue Date: 01 June 2002 * DOI: https://doi.org/10.1038/sj.jp.7210698 SHARE THIS ARTICLE Anyone you

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