The drd2 taqi-b polymorphism and its relationship to smoking abstinence and withdrawal symptoms

ABSTRACT The dopamine receptor D2 (_DRD2_) gene has polymorphisms that have been linked to regulation of the dopamine system and to an increased prevalence of smoking. The present study

examined the relationship of the _DRD2 Taq_I-A and -B polymorphisms with short-term clinical outcome (abstinence and withdrawal symptoms), collected from daily (14 pre-quit and 42 post-quit)

diary data among smokers (_n_=116) treated with the nicotine patch plus either venlafaxine or placebo. The results showed that B1/B1 or B1/B2 smokers were slightly less likely to be

abstinent on a given day than those homozygous for the _Taq_I-B2 allele. Significant _DRD2 Taq_I-B × time interactions were found for several of the withdrawal scales, indicating that those

smokers with the B1/B1 or B1/B2 genotypes tended to report more symptoms over time compared to those with the B2/B2 genotype. No interactions or main effects were found for the _DRD2 Taq_I-A

polymorphism. The findings demonstrate that smokers homozygous for the _Taq_I-B2 allele experience progressive improvement in self-reported withdrawal symptoms while smokers with the

_Taq_I-B1 allele showing little change. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through

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Article Open access 22 June 2022 SMOKERS WITH HIGHER POSITIVE OR NEGATIVE URGENCY HAVE LOWER RATES OF SMOKING CESSATION SUCCESS 12 MONTHS AFTER A QUIT ATTEMPT Article Open access 29 May 2024

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references ACKNOWLEDGEMENTS Support for this research was provided by grants from the MD Anderson Cancer Center (PRS), the National Cancer Institute (SPORE P50CA70907), and the National

Institute on Drug Abuse (R01DA1182-01) to Paul M Cinciripini and MD Anderson Education Program in Cancer Prevention Postdoctoral Fellowship Grants (R25 CA57730) to Jason D Robinson, Cho Y

Lam and Jennifer A Minnix. Study medication and nicotine patches were provided by Wyeth-Ayerst Laboratories. Portions of this research were presented at the annual meeting of the Society for

Research on Nicotine and Tobacco, Orlando, Florida, February 2006. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Behavioral Science, The University of Texas MD Anderson Cancer

Center, Houston, TX, USA J D Robinson, C Y Lam, J A Minnix & P M Cinciripini * Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX,

USA D W Wetter * Pediatric Hematology-Oncology Division, The Harold C Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA G E

Tomlinson * Hamon Center for Therapeutic Oncology Research, The Harold C Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA

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AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Robinson, J., Lam, C., Minnix, J. _et al._ The _DRD2 Taq_I-B polymorphism and its relationship to smoking

abstinence and withdrawal symptoms. _Pharmacogenomics J_ 7, 266–274 (2007). https://doi.org/10.1038/sj.tpj.6500427 Download citation * Received: 06 June 2006 * Revised: 02 October 2006 *

Accepted: 09 October 2006 * Published: 26 December 2006 * Issue Date: 01 August 2007 * DOI: https://doi.org/10.1038/sj.tpj.6500427 SHARE THIS ARTICLE Anyone you share the following link with

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content-sharing initiative KEYWORDS * _DRD2_ * _Taq_I-A * _Taq_I-B * smoking * withdrawal * abstinence