Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus

ABSTRACT The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus. Our study

includes 711 systemic lupus erythematosus (SLE) patients and 755 healthy controls. We genotyped the migration inhibitory factor (MIF) −173G/C using a polymerase chain reaction (PCR) system

with predeveloped TaqMan allelic discrimination assay and the MIF −794 CATT_n_ microsatellite polymorphism using a PCR-fluorescent method. A statistically significant difference in the

distribution of the MIF −173*C allele between SLE patients and controls (_P_=0.004, OR=1.34, 95% CI=1.05–1.27) was observed. In addition, the frequency of the MIF −173*C/C genotype was

higher in SLE patient (_P_=0.002, OR=2.58, 95% CI=1.32–5.10). No differences in the distribution of CATT_n_ were found. However, the haplotypes analyses showed that only the CATT7-MIF −173*C

haplotype was associated with a higher susceptibility to SLE (_P_=0.001, OR 1.84, 95% CI 1.35–2.79). No association with clinical features was detected in any case. These results suggest

that both, MIF −173*C allele and CATT7-MIF −173*C haplotype, confer susceptibility to SLE in our population. Access through your institution Buy or subscribe This is a preview of

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references ACKNOWLEDGEMENTS This work was supported by Grant SAF03-3460 from Plan Nacional de I+D+I, and in part by the Junta de Andalucía, grupo CTS-180. We thank Ma Paz Ruiz and Sasha

Zhernakova for her excellent technical assistance. Finally, we thank Cisca Wijmenga for support. AUTHOR INFORMATION Author notes * E Sánchez, L M Gómez, B P Koeleman and J Martín: These

authors contributed equally to this work AUTHORS AND AFFILIATIONS * Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain E Sánchez & J Martín * Unidad de Biología

Celular e Inmunogenética, Corporación para investigaciones biologicas (CIB), Medellín, Colombia L M Gómez * Servicio de Inmunologia. Hospital Virgen de las Nieves, Granada, Spain M A

Lopez-Nevot * Servicio de Reumatología. Hospital Xeral-Calde, Lugo, Spain M A González-Gay * Servicio de Medicina Interna. Hospital Virgen de las Nieves, Granada, Spain J M Sabio * Servicio

de Medicina Interna. Hospital Clínico San Cecilio, Granada, Spain N Ortego-Centeno * Servicio de Medicina Interna. Hospital Carlos-Haya, Málaga, Spain E de Ramón * Unidad de Biología Celular

e Inmunogenética, Corporación para investigaciones biologies (CIB), Universidad del Rosario, Medellín, Colombia J M Anaya * Servicio de Inmunología. Hospital Virgen del Rocío, Sevilla,

Spain M F González-Escribano * Department of Biomedical Genetics, Utrecht University Medical Centre, Utrecht, The Netherlands B P Koeleman Authors * E Sánchez View author publications You

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PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Sánchez, E., Gómez, L., Lopez-Nevot, M. _et al._ Evidence of association of macrophage migration inhibitory factor

gene polymorphisms with systemic lupus erythematosus. _Genes Immun_ 7, 433–436 (2006). https://doi.org/10.1038/sj.gene.6364310 Download citation * Received: 15 March 2006 * Revised: 21 April

2006 * Accepted: 21 April 2006 * Published: 18 May 2006 * Issue Date: 01 July 2006 * DOI: https://doi.org/10.1038/sj.gene.6364310 SHARE THIS ARTICLE Anyone you share the following link with

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content-sharing initiative KEYWORDS * polymorphism * systemic lupus erythematosus * macrophage migration inhibitory factor * inflammation