Linkage and association between plasmodium falciparum blood infection levels and chromosome 5q31–q33

ABSTRACT We have previously mapped a locus controlling _Plasmodium falciparum_ blood infection levels (PFBI) to chromosome 5q31–q33. We genotyped 19 microsatellite markers on chromosome

5q31–q33 in a new sample of 44 pedigrees comprising 84 nuclear families and 292 individuals living in a _P. falciparum_ endemic area. Using a nonparametric multipoint variance-component

approach (by GENEHUNTER), we evidenced a peak of linkage close to D5S636 (_P_=0.0069), with a heritability of 0.46. Using a variance-component method for linkage-disequilibrium mapping of

quantitative traits (by QTDT) and the Bonferroni correction for multiple testing, we further detected allelic association in the presence of linkage between blood infection levels and D5S487

(_P_=6 × 10−5; _P__c_=0.0011), which is located on the distal part of the peak. These results confirm the importance of chromosome 5q31–q33 in the genetic control of PFBI levels. Access

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support SIMILAR CONTENT BEING VIEWED BY OTHERS MALARIA PROTECTION DUE TO SICKLE HAEMOGLOBIN DEPENDS ON PARASITE GENOTYPE Article Open access 09 December 2021 THE IMPACT OF

MALARIA-PROTECTIVE RED BLOOD CELL POLYMORPHISMS ON PARASITE BIOMASS IN CHILDREN WITH SEVERE _PLASMODIUM FALCIPARUM_ MALARIA Article Open access 08 June 2022 GENOMICS REVEALS HETEROGENEOUS

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references ACKNOWLEDGEMENTS This research was supported by the French Ministry of Research and Technology, the Fondation pour la Recherche Médicale (France), the Conseil Régional Provence

Alpes Côte d'Azur (France), and the Conseil Général des Bouches du Rhône (France). BK and CA were, respectively, supported by studentships from the Agence Universitaire de la

Francophonie and the Fondation pour la Recherche Médicale. LF is supported by a studentship from the French Ministry of Research and Technology. AUTHOR INFORMATION Author notes * L Flori and

B Kumulungui: Both authors equally contributed to this work. AUTHORS AND AFFILIATIONS * Université de la Méditerranée, Marseille, France L Flori, C Aucan, C Esnault, F Fumoux & P Rihet

* Université de Ouagadougou, Burkina Faso B Kumulungui & A S Traoré Authors * L Flori View author publications You can also search for this author inPubMed Google Scholar * B Kumulungui

View author publications You can also search for this author inPubMed Google Scholar * C Aucan View author publications You can also search for this author inPubMed Google Scholar * C

Esnault View author publications You can also search for this author inPubMed Google Scholar * A S Traoré View author publications You can also search for this author inPubMed Google Scholar

* F Fumoux View author publications You can also search for this author inPubMed Google Scholar * P Rihet View author publications You can also search for this author inPubMed Google

Scholar CORRESPONDING AUTHOR Correspondence to P Rihet. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Flori, L., Kumulungui, B., Aucan, C. _et al._

Linkage and association between _Plasmodium falciparum_ blood infection levels and chromosome 5q31–q33. _Genes Immun_ 4, 265–268 (2003). https://doi.org/10.1038/sj.gene.6363960 Download

citation * Published: 22 May 2003 * Issue Date: 01 June 2003 * DOI: https://doi.org/10.1038/sj.gene.6363960 SHARE THIS ARTICLE Anyone you share the following link with will be able to read

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KEYWORDS * _Plasmodium falciparum_ * malaria * parasitemia * genetic linkage * variance components * quantitative transmission/disequilibrium test