Molecular biology: solo signal


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_Cell_ 136, 411–419 (2009) 10.1016/j.cell.2009.01.023 For skin, liver or stomach cells to behave like embryonic stem cells, researchers have so far had to add to them at least three genes


that have been linked to cancer. But only one such gene, which encodes a molecule called Oct4 (and also Pou5F1), is needed to induce pluripotency — the ability to develop into most cell


types — in mouse neural stem cells. Unlike most successful attempts to reprogram cells, which take about three weeks, this approach by Hans Schöler of the Max Planck Institute for Molecular


Biomedicine in Münster, Germany, and his co-workers took four to five weeks of culturing. Nonetheless, the efficiency of the reprogramming was roughly equal to that of mouse embryonic skin


cells when Oct4 and three other reprogramming factors are added to them. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Molecular biology: Solo signal.


_Nature_ 457, 766 (2009). https://doi.org/10.1038/457766e Download citation * Published: 01 February 2009 * Issue Date: 12 February 2009 * DOI: https://doi.org/10.1038/457766e SHARE THIS


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