Kai1 expression can be a predictor of stage a prostate cancer progression

ABSTRACT The disease progression and rate of cancer death were analyzed in 52 patients with stage A prostate cancer who underwent transurethral resection of the prostate (TURP) or retropubic

subcapsular prostatectomy (SCP) between 1987 and 1998. We performed immunohistochemistry on 16 patients to determine the correlation between the expression of the tumor metastasis

suppressor gene KAI1 and the subsequent progression of stage A prostate cancer. Nineteen and 33 of the patients had cancer at stage A1 and stage A2, respectively, and their subsequent

courses were followed for an average of 53.7 months (24–134 months). Progression to clinical cancer was found in six patients (one with stage A1, and five with stage A2). This progression

was evident 40.8 months (5–80 months) after TURP or SCP. Four (66.7%) of the patients died of cancer progression (average 31 months) after prostatectomy. All four patients had stage A2,

poorly differentiated adenocarcinoma, and had been followed with administration of diethylstilbestrol diphosphate (DES-P). The disease-free patients (_n_=10) showed overexpression of KAI1

protein, compared to those with disease progression (_n_=6). These results indicate that progression arose mainly in the patients with stage A2 cancer, and that poorly differentiated, focal

and weak expression of KAI1 protein is highly associated with disease progression. It is suggested that patients in this group should be treated with immediate total androgen blockade,

radiation, or radical prostatectomy after diagnosis. . Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS

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AND AFFILIATIONS * Department of Urology, Nagoya City University Medical School, Nagoya, Japan K Tozawa, N Kawai, S Sasaki, Y Hayashi & K Kohri * Department of Urology, Meijo Hospital,

Nagoya, Japan H Akita & T Okamura Authors * K Tozawa View author publications You can also search for this author inPubMed Google Scholar * H Akita View author publications You can also

search for this author inPubMed Google Scholar * N Kawai View author publications You can also search for this author inPubMed Google Scholar * T Okamura View author publications You can

also search for this author inPubMed Google Scholar * S Sasaki View author publications You can also search for this author inPubMed Google Scholar * Y Hayashi View author publications You

can also search for this author inPubMed Google Scholar * K Kohri View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Tozawa, K., Akita, H., Kawai, N. _et al._ KAI1 expression can be a predictor of stage A prostate cancer progression. _Prostate Cancer

Prostatic Dis_ 4, 150–153 (2001). https://doi.org/10.1038/sj.pcan.4500521 Download citation * Received: 11 July 2000 * Revised: 23 February 2001 * Accepted: 14 March 2001 * Published: 04

October 2001 * Issue Date: 01 September 2001 * DOI: https://doi.org/10.1038/sj.pcan.4500521 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

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cancer * progression * KAI1 protein