Disrupted-in-schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth

ABSTRACT _Disrupted-In-Schizophrenia 1_ (_DISC1_) was identified as a novel gene disrupted by a (1;11)(q42.1;q14.3) translocation that segregated with schizophrenia in a Scottish family.

Predicted _DISC1_ product has no significant homology to other known proteins. Here, we demonstrated the existence of DISC1 protein and identified fasciculation and elongation protein zeta-1

(FEZ1) as an interacting partner of DISC1 by a yeast two-hybrid study. FEZ1 and its nematode homolog are reported to represent a new protein family involved in axonal outgrowth and

fasciculation. In cultured hippocampal neurons, DISC1 and FEZ1 colocalized in growth cones. Interactions of these proteins were associated with F-actin. In the course of neuronal

differentiation of PC12 cells, upregulation of DISC1/FEZ1 interaction was observed as along with enhanced extension of neurites by overexpression of DISC1. The present study shows that

_DISC1_ participates in neurite outgrowth through its interaction with FEZ1. Recent studies have provided reliable evidence that schizophrenia is a neurodevelopmental disorder. As there is a

high level of _DISC1_ expression in developing rat brain, dysfunction of DISC1 may confer susceptibility to psychiatric illnesses through abnormal development of the nervous system. Access

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SIMILAR CONTENT BEING VIEWED BY OTHERS THE 22Q11.2 REGION REGULATES PRESYNAPTIC GENE-PRODUCTS LINKED TO SCHIZOPHRENIA Article Open access 27 June 2022 PATHOGENIC _TRIO_ VARIANTS ASSOCIATED

WITH NEURODEVELOPMENTAL DISORDERS PERTURB THE MOLECULAR REGULATION OF TRIO AND AXON PATHFINDING IN VIVO Article 30 January 2023 IMPAIRED OTUD7A-DEPENDENT ANKYRIN REGULATION MEDIATES NEURONAL

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for Neuroscience 32nd Annual Meeting_, 2002. Download references ACKNOWLEDGEMENTS We acknowledge Drs A Sawa (Johns Hopkins University), N Mori and N Takei (Hamamatsu University School of

Medicine), K Tanizawa and J Takeda (Osaka University) for critical reading of the manuscript and for valuable discussions and encouragement. AUTHOR INFORMATION Author notes * K Miyoshi and A

Honda: Both contributed equally to this work. AUTHORS AND AFFILIATIONS * Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Japan K Miyoshi, A

Honda, K Baba, M Taniguchi, K Oono, T Katayama & M Tohyama * Discovery Research Laboratory, Tanabe Seiyaku Company Limited, Osaka, Japan A Honda * CREST of Japan Science and Technology

Corporation (JST), Kawaguchi, Japan K Miyoshi, A Honda, K Baba, M Taniguchi, K Oono, T Katayama & M Tohyama * Department of Structural Molecular Biology, Institute of Scientific and

Industrial Research, Osaka University, Ibaraki, Japan T Fujita & S Kuroda Authors * K Miyoshi View author publications You can also search for this author inPubMed Google Scholar * A

Honda View author publications You can also search for this author inPubMed Google Scholar * K Baba View author publications You can also search for this author inPubMed Google Scholar * M

Taniguchi View author publications You can also search for this author inPubMed Google Scholar * K Oono View author publications You can also search for this author inPubMed Google Scholar *

T Fujita View author publications You can also search for this author inPubMed Google Scholar * S Kuroda View author publications You can also search for this author inPubMed Google Scholar

* T Katayama View author publications You can also search for this author inPubMed Google Scholar * M Tohyama View author publications You can also search for this author inPubMed Google

Scholar CORRESPONDING AUTHOR Correspondence to T Katayama. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Miyoshi, K., Honda, A., Baba, K. _et al._

_Disrupted-In-Schizophrenia 1_, a candidate gene for schizophrenia, participates in neurite outgrowth. _Mol Psychiatry_ 8, 685–694 (2003). https://doi.org/10.1038/sj.mp.4001352 Download

citation * Received: 07 December 2002 * Revised: 18 February 2003 * Accepted: 11 March 2003 * Published: 22 July 2003 * Issue Date: 01 July 2003 * DOI: https://doi.org/10.1038/sj.mp.4001352

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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * DISC1 * FEZ1 * mental disorders * schizophrenia * cytoskeleton * neurites