Genetic association of acyl-coenzyme a: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for alzheimer's disease

ABSTRACT A common polymorphism of the gene encoding acyl-coenzyme A: cholesterol acyltransferase 1 (_SOAT1_), which is involved in the regulation of _β_-amyloid peptide generation, is

associated with low brain amyloid load (_P_=0.03) and with low cerebrospinal fluid levels of cholesterol (_P_=0.005). This polymorphism of _SOAT1_ is also associated with reduced risk for

Alzheimer's disease in ethnically distinct populations (_P_=0.0001, odds ratio: 0.6, 95% confidence interval 0.4–0.8). Access through your institution Buy or subscribe This is a preview

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Download references ACKNOWLEDGEMENTS We thank Ms. Esmeralda Garcia, Ms Christin Wilde, Mrs Andrea Walther, and Ms Estelle Obrist for their patient care and sampling. The technical expertise

of Ms Anja Kerksiek is gratefully acknowledged. This work was supported in parts by grants of the Swiss Science National Foundation (32-65869.01) and the Roche Research Foundation (22-2001)

to AP, by the Bundesministerium für Bildung, Forschung, Wissenschaft und Technologie (01EC9402) to DL and KvB, by the National Center for Competence in Research (NCCR) ‘Neuronal Plasticity

and Repair’, and by the EU DIADEM program on Diagnosis of Dementia. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Psychiatry Research, University of Zürich, Switzerland M A

Wollmer, J R Streffer, R M Nitsch, C Hock & A Papassotiropoulos * Third Department of Neurology, Aristotle University of Thessaloniki, Greece M Tsolaki * Department of Neuroscience,

Neuroimmunology Unit, IRCCS H. San Raffaele, Italy L M E Grimaldi * Department of Neuroscience, AUSL n.2, Caltanissetta, Italy L M E Grimaldi * Department of Clinical Pharmacology,

University of Bonn Medical Center, Germany D Lütjohann & K von Bergmann * Institute of Neuropathology, University of Bonn Medical Center, Germany D Thal Authors * M A Wollmer View author

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Streffer, J., Tsolaki, M. _et al._ Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for

Alzheimer's disease. _Mol Psychiatry_ 8, 635–638 (2003). https://doi.org/10.1038/sj.mp.4001296 Download citation * Received: 26 June 2002 * Revised: 06 October 2002 * Accepted: 10

October 2002 * Published: 08 July 2003 * Issue Date: 01 June 2003 * DOI: https://doi.org/10.1038/sj.mp.4001296 SHARE THIS ARTICLE Anyone you share the following link with will be able to

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initiative KEYWORDS * SNP * polymorphism * ACAT1 * SOAT1 * case–control study * dementia