No evidence for a direct effect of clozapine on fat-cell formation and production of leptin and other fat-cell-derived factors

Access through your institution Buy or subscribe Atypical neuroleptics are known to induce substantial weight gain in a considerable proportion of patients within a few months of treatment.1

Among the currently available atypical antipsychotic drugs clozapine appears to have the greatest weight-increasing potential.2 To understand the underlying mechanisms, we examined whether

clozapine has an effect on human adipocyte development and specific functions of mature fat cells such as glucose transport, lipolysis, and production and secretion of leptin, interleukin-6

(IL-6) and plasminogen activator inhibitor-1 (PAI-1). The results of our _in vitro_ study do not provide evidence for a direct effect of clozapine on these functions arguing that central

rather than peripheral mechanisms may induce weight gain and the metabolic disturbances under clozapine treatment. Little is currently known about the mechanisms of weight gain by atypical

neuroleptics. One common hypothesis is that patients experience a lower suppression of appetite after meals indicating that the perception of satiety may be impaired.1 Interestingly,

clozapine was recently found to increase serum leptin levels within days after initiation of treatment.3,4 To get more insight into the pathophysiology of clozapine-induced weight gain, we

studied the effect of the drug on fat cell formation and selected metabolic and secretory functions of human adipose tissue. This is a preview of subscription content, access via your

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article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in

* Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Leadbetter R, Shutty M, Pavalonis D, Nvieweg V, Higgins P, Downs M . _Am J Psychiatry_ 1992;

149: 68–72. * Allison DB _et al_. _Am J Psychiatry_ 1999; 156: 1686–1696. * Brömel T, Blum WF, Ziegler A _et al_. _Mol Psychiatry_ 1998; 3: 76–80. * Kraus T _et al_. _Am J Psychiatry_ 1999;

156: 312–314. * Hauner H, Skurk T, Wabitsch M . _Meth Mol Biol_ 2001; 155: 239–247. * Gottschling-Zeller H, Birgel M, Scriba D, Blum WF, Hauner H . _Eur J Endocrinol_ 1999; 141: 436–442. *

Hauner H, Petruschke T, Russ M, Röhrig K, Eckel J . _Diabetologia_ 1995; 38: 764–771. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * German

Diabetes Research Institute, Heinrich-Heine-University Düsseldorf, Auf'm Hennekamp 65, Düsseldorf, 40225, Germany H Hauner, K Röhrig & Th Skurk * Department of Child and Adolescent

Psychiatry of the University of Marburg, Clinical Research Group, Marburg, 35033, Germany J Hebebrand Authors * H Hauner View author publications You can also search for this author inPubMed

 Google Scholar * K Röhrig View author publications You can also search for this author inPubMed Google Scholar * J Hebebrand View author publications You can also search for this author

inPubMed Google Scholar * Th Skurk View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to H Hauner. RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hauner, H., Röhrig, K., Hebebrand, J. _et al._ No evidence for a direct effect of clozapine on fat-cell formation

and production of leptin and other fat-cell-derived factors. _Mol Psychiatry_ 8, 258–259 (2003). https://doi.org/10.1038/sj.mp.4001246 Download citation * Published: 27 March 2003 * Issue

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