It all sticks together—the app-related family of proteins and alzheimer's disease

ABSTRACT In the present review, we shall discuss the pros and cons of a possible functional relationship and contribution of the APP family members (APP, APLP1 and APLP2) to the development

of Alzheimer's disease: (1) APP, APLP1 and APLP2 are highly homologous proteins with similar protein domain organization. (2) All APP family proteins have been found to be aggregated in

typical Alzheimer's disease lesions. (3) Several other proteins have been implied to provide a functional link among the APP-related proteins. In normal adult brain APP, APLP1 and

APLP2 are involved in synaptic processes important for memory function. We hypothesize that the functional loss of members of the APP family contributes to the gradual cognitive decline in

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COMPILATION OF REPORTED PROTEIN CHANGES IN THE BRAIN IN ALZHEIMER’S DISEASE Article Open access 25 July 2023 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Psychiatry,

University of Bonn Medical Center, Sigmund-Freud-Strasse 25, Bonn, 53105, Germany T A Bayer * Department of Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia R Cappai 

& C L Masters * ZMBH, Im Neuenheimer Feld 282, Heidelberg, 69120, Germany K Beyreuther & G Multhaup Authors * T A Bayer View author publications You can also search for this author

inPubMed Google Scholar * R Cappai View author publications You can also search for this author inPubMed Google Scholar * C L Masters View author publications You can also search for this

author inPubMed Google Scholar * K Beyreuther View author publications You can also search for this author inPubMed Google Scholar * G Multhaup View author publications You can also search

for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to T A Bayer. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bayer, T.,

Cappai, R., Masters, C. _et al._ It all sticks together—the APP-related family of proteins and Alzheimer's disease. _Mol Psychiatry_ 4, 524–528 (1999).

https://doi.org/10.1038/sj.mp.4000552 Download citation * Received: 02 December 1998 * Revised: 01 March 1999 * Accepted: 08 March 1999 * Published: 16 November 1999 * Issue Date: 01

November 1999 * DOI: https://doi.org/10.1038/sj.mp.4000552 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * APP * APLP1 * APLP2