Acute stimulation of glucose metabolism in mice by leptin treatment

ABSTRACT Leptin is an adipocyte hormone that functions as an afferent signal in a negative feedback loop regulating body weight1,2,3,4, and acts by interacting with a receptor in the

hypothalamus and other tissues5,6. Leptin treatment has potent effects on lipid metabolism, and leads to a large, specific reduction of adipose tissue mass after several days1,4. Here we

show that leptin also acts acutely to increase glucose metabolism, although studies of leptin's effect on glucose metabolism have typically been confounded by the weight-reducing

actions of leptin treatment, which by itself could affect glucose homoeostasis1,2,3. We have demonstrated acute _in vivo_ effects of intravenous and intracerebroventricular administrations

of leptin on glucose metabolism. A five-hour intravenous infusion of leptin into wild-type mice increased glucose turnover and glucose uptake, but decreased hepatic glycogen content. The

plasma levels of insulin and glucose did not change. Similar effects were observed after both intravenous and intracerebroventricular infusion of leptin, suggesting that effects of leptin on

glucose metabolism are mediated by the central nervous system (CNS). These data indicate that leptin induces a complex metabolic response with effects on glucose as well as lipid

metabolism. This response is unique to leptin, which suggests that new efferent signals emanate from the CNS after leptin treatment. Access through your institution Buy or subscribe This is

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SYSTEM INHIBITION ENHANCES CARDIAC METABOLISM AND IMPROVES HEMODYNAMICS AND GLUCOSE-INSULIN DYNAMICS IN OBESE AND LEAN RAT MODELS Article Open access 02 January 2025 CENTRAL NERVOUS SYSTEM

REGULATION OF ORGANISMAL ENERGY AND GLUCOSE HOMEOSTASIS Article 21 June 2021 LEPTIN ALTERS ENERGY INTAKE AND FAT MASS BUT NOT ENERGY EXPENDITURE IN LEAN SUBJECTS Article Open access 13

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269, E1037–E1043 (1995). CAS  PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS We thank E. B. Katz, C. Vaisse, J. Li and T. S. Tsao for discussions; J. Blaire-West and D. A.

Denton for help with the ICV surgery; S. Korres for helping to prepare the manuscript; and Amgen for recombinant leptin. This work was supported by grants from the NIH (J.M.F. and M.J.C.),

Pew Charitable Trust (M.J.C.), Juvenile Diabetes Foundation International (R.B.), the Philippe Foundation (R.B.) and the Manpei Suzuki Diabetes Foundation (S.K.). AUTHOR INFORMATION Author

notes * Seika Kamohara and Rémy Burcelin: These authors contributed equally to this work. AUTHORS AND AFFILIATIONS * Laboratory of Molecular Genetics, the Rockefeller University, 1230 York

Avenue, New York, 10021, New York, USA Seika Kamohara, Jeffrey L. Halaas & Jeffrey M. Friedman * Howard Hughes Medical Institute, the Rockefeller University, 1230 York Avenue, New York,

10021, New York, USA Jeffrey M. Friedman * Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, 10461, New York, USA Rémy Burcelin & Maureen

J. Charron Authors * Seika Kamohara View author publications You can also search for this author inPubMed Google Scholar * Rémy Burcelin View author publications You can also search for this

author inPubMed Google Scholar * Jeffrey L. Halaas View author publications You can also search for this author inPubMed Google Scholar * Jeffrey M. Friedman View author publications You

can also search for this author inPubMed Google Scholar * Maureen J. Charron View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR

Correspondence to Maureen J. Charron. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kamohara, S., Burcelin, R., Halaas, J. _et al._ Acute stimulation

of glucose metabolism in mice by leptin treatment. _Nature_ 389, 374–377 (1997). https://doi.org/10.1038/38717 Download citation * Received: 02 June 1997 * Accepted: 18 July 1997 * Issue

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