In Brief | Nature Reviews Molecular Cell Biology


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Access through your institution Buy or subscribe REORGANIZATION OF MULTIVESICULAR BODIES REGULATES MHC CLASS II ANTIGEN PRESENTATION BY DENDRITIC CELLS. Kleijmeer, M. _et al_. _J. Cell


Biol._ 155, 53?63 (2001) [PubMed] The maturation of dendritic cells ? antigen-presenting cells that initiate primary T-cell responses ? is characterized by the redistribution of MHC II


molecules from the internal membranes of multivesicular bodies to the external membranes of these organelles. There, MHC II encounters DM, an accessory molecule required for peptide loading.


The mechanism through which mixing of internal and external membranes occurs is not well understood, but this relocalization could prove important in regulating loading of MHC II antigens.


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permissions ABOUT THIS ARTICLE CITE THIS ARTICLE In Brief. _Nat Rev Mol Cell Biol_ 2, 787 (2001). https://doi.org/10.1038/35099048 Download citation * Issue Date: November 2001 * DOI:


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